N-Benzyl-4-piperidone, identified by CAS number 3612-20-2, is a cornerstone chemical intermediate, particularly valued in the pharmaceutical sector. Its utility is deeply rooted in its distinct chemical and physical properties, which enable its crucial role in synthesizing complex drug molecules like Remifentanil. A thorough understanding of these attributes is essential for chemists and manufacturers working with this compound.

Physically, N-Benzyl-4-piperidone is described as a light yellow to brown liquid. This appearance is a standard characteristic for many organic intermediates and provides a basic visual cue for identification. More significantly, its density is approximately 1.1±0.1 g/cm³, a value that contributes to its handling and processing characteristics in industrial settings. The boiling point, recorded at a relatively high 278.5±0.0 °C at standard atmospheric pressure (760 mmHg), indicates its thermal stability under certain conditions, which is important for reactions requiring elevated temperatures.

Chemically, the compound's molecular formula is C12H15NO, with a molecular weight of 189.254. This precise molecular structure, featuring a piperidone ring with a benzyl substituent, is what makes it so effective as a building block in organic synthesis. The functional groups present allow it to participate in specific, controlled chemical reactions necessary for creating more complex molecular architectures.

A critical property for its pharmaceutical application is its high purity. Typically, N-Benzyl-4-piperidone is supplied with an assay of ≥98.0%. This high level of purity is rigorously maintained through advanced purification techniques. Furthermore, stringent controls are placed on impurities, with single impurities usually limited to ≤1.0% and total impurities not exceeding 2.0%. This adherence to quality standards ensures that the compound is suitable for use in the demanding environment of drug manufacturing, where consistency and minimal contamination are paramount.

The flash point of 130.8±11.9 °C suggests that, while combustible, N-Benzyl-4-piperidone can be handled safely with appropriate precautions in well-ventilated areas, which is a standard consideration for industrial chemicals. Its storage recommendations—in cool, ventilated places—further ensure its stability and quality over time. When considering the price of N-Benzyl-4-piperidone, these intrinsic properties and the manufacturing efforts to maintain them are key factors.

In summary, the physical and chemical profile of N-Benzyl-4-piperidone, from its liquid state and density to its precise molecular structure and exceptional purity, firmly establishes its value as a key intermediate in the pharmaceutical industry, particularly for complex syntheses like that of Remifentanil.