At NINGBO INNO PHARMCHEM CO.,LTD., we recognize that advancements in medicine are built upon a foundational understanding of chemical compounds. Epacadostat, a molecule of significant interest in immuno-oncology, exemplifies this principle. Its unique chemical structure and properties are the basis for its therapeutic potential as an IDO1 inhibitor, driving research in cancer immunotherapy.

The chemical name for Epacadostat is N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine, with the CAS number 1204669-58-8. This complex structure features a 1,2,5-oxadiazole core, a hydroxyamidine group, and a bromofluorophenyl substituent, all contributing to its specific biological activity. The epacadostat mechanism of action is directly linked to these structural features, allowing it to selectively bind to and inhibit the enzyme IDO1. Understanding these chemical details is crucial for its effective use in research and development.

Physically, Epacadostat is typically a white solid, demonstrating good solubility in DMSO, which is advantageous for its use in various in vitro assays. Its molecular weight and formula (C11H13BrFN7O4S) are critical identifiers for purity and characterization. The development of oral IDO1 inhibitors for immune response modulation, like Epacadostat, is a testament to the intricate chemistry involved in creating bioavailable and effective therapeutic agents. NINGBO INNO PHARMCHEM CO.,LTD. ensures the purity and consistency of such compounds for research applications.

The research applications of Epacadostat are vast, primarily focusing on its role in enhancing anti-tumor immunity. Its investigation in epacadostat in clinical trials, often in combination with checkpoint inhibitors, stems from its ability to modulate the tumor microenvironment and improve immune cell function. The IDO1 selective inhibitor benefits are being thoroughly explored in these contexts, aiming to overcome treatment resistance and improve patient outcomes. This aligns with the broader goals of advanced cancer immunotherapy strategies.

By providing access to meticulously characterized compounds like Epacadostat, NINGBO INNO PHARMCHEM CO.,LTD. supports critical research into novel therapeutic pathways. The study of such molecules is fundamental to the progress of research chemicals for oncology and the continuous innovation in fighting cancer.