The constant drive for innovation in pharmaceutical research necessitates access to versatile and high-quality chemical intermediates. N-Boc-D-phenylalaninol, recognized by its CAS number 106454-69-7, exemplifies such a compound. Its unique chemical structure, featuring both a chiral center and a protecting group, makes it an exceptionally useful tool in the synthesis of complex molecules, particularly in the pharmaceutical sector. This article explores the chemical versatility of N-Boc-D-phenylalaninol and its significant role in advancing drug discovery and development.

At its core, N-Boc-D-phenylalaninol is a protected derivative of the amino acid D-phenylalanine. The tert-butyloxycarbonyl (Boc) group attached to the amine nitrogen serves as a critical protective element. This group is renowned for its stability under a variety of reaction conditions, yet it can be readily cleaved under mild acidic treatment, allowing for controlled deprotection. This dual characteristic—stability during synthesis and ease of removal—is fundamental to its widespread use. Physically, it is typically supplied as a white to light yellow crystalline powder, with a melting point of 95-98°C, underscoring its solid, stable nature.

The chirality of N-Boc-D-phenylalaninol, indicated by its specific rotation of +24°(23℃, c=1, CHCl3), is paramount in its application in the synthesis of chiral drugs. Many modern pharmaceuticals exhibit stereospecific biological activity, meaning only one enantiomer provides the desired therapeutic effect while the other may be inactive or even harmful. N-Boc-D-phenylalaninol provides a reliable chiral scaffold, enabling the synthesis of enantiomerically pure drug candidates. Its role as an intermediate in the preparation of (S)-Amphetamine is a testament to its utility in precise stereoselective synthesis. This makes it an invaluable component for researchers engaged in chiral synthesis and the development of targeted therapies.

The versatility of N-Boc-D-phenylalaninol extends into broader organic synthesis. It serves as a foundational building block for constructing complex organic frameworks, facilitating the creation of novel chemical entities. Its incorporation into peptide synthesis, for instance, can introduce specific structural motifs that influence the biological activity or stability of the resulting peptide. The compound's predictable reactivity and the well-established protocols for Boc group manipulation make it a favored choice for chemists aiming to streamline complex synthetic routes and enhance overall yields. The availability of high-purity N-Boc-D-phenylalaninol CAS 106454-69-7 properties is key for reproducibility.

Companies like Ningbo Inno Pharmchem Co., Ltd. play a crucial role in making such essential intermediates accessible to the scientific community. By providing high-quality N-Boc-D-phenylalaninol, they support the vital work of researchers and manufacturers in developing new medicines. For those looking to purchase N-Boc-D-phenylalaninol, partnering with reliable suppliers ensures the availability of material that meets the rigorous demands of pharmaceutical research and pharmaceutical intermediate production. Their commitment to quality bolsters the field of organic synthesis building blocks.

In conclusion, the chemical versatility of N-Boc-D-phenylalaninol (CAS: 106454-69-7) makes it an indispensable compound in contemporary drug discovery and organic synthesis. Its unique combination of a chiral center, a robust protecting group, and high purity solidifies its position as a key enabler of innovation in the pharmaceutical industry.