In the intricate world of synthetic organic chemistry, certain molecules serve as foundational elements for a vast array of applications. Boc-D-4-Iodophenylalanine, with its CAS number 176199-35-2, is one such critical intermediate. This article, presented by NINGBO INNO PHARMCHEM CO.,LTD., aims to shed light on the chemistry of this compound, from its synthesis to its diverse industrial and research applications.

Boc-D-4-Iodophenylalanine is a protected amino acid, specifically a derivative of the naturally occurring amino acid phenylalanine. Its chemical structure is characterized by the presence of a tert-butyloxycarbonyl (Boc) group attached to the alpha-amino nitrogen and an iodine atom substituted at the para-position of the phenyl ring. The Boc group is a widely used protecting group in peptide synthesis and organic synthesis. It is stable under a variety of reaction conditions but can be readily removed by treatment with mild acids, such as trifluoroacetic acid (TFA), unmasking the amine for further reactions. This selective deprotection is key to building complex peptide chains step-by-step.

The iodine substituent on the phenyl ring imparts significant functionality to Boc-D-4-Iodophenylalanine. Iodine is a heavy atom that can influence the electronic and steric properties of the molecule. More importantly, the carbon-iodine bond is susceptible to nucleophilic substitution and is an excellent substrate for various transition-metal catalyzed cross-coupling reactions, such as palladium-catalyzed couplings (e.g., Suzuki, Stille, Heck reactions). These reactions allow chemists to attach a wide range of other molecular fragments to the phenylalanine core, creating highly customized molecules. This versatility makes Boc-D-4-Iodophenylalanine a sought-after building block for synthesizing complex organic molecules, including pharmaceuticals, agrochemicals, and materials with unique properties.

In the context of peptide synthesis, the incorporation of unnatural amino acids like Boc-D-4-Iodophenylalanine can lead to peptides with altered or enhanced biological activities. For instance, the bulky iodine atom can influence the conformation of the peptide backbone, affecting its interaction with biological targets. Researchers actively seek reliable sources to purchase Boc-D-4-Iodophenylalanine for these specialized peptide synthesis applications. The consistent quality and purity provided by reputable Boc-D-4-Iodophenylalanine manufacturers are essential for the reproducibility of experimental results.

Moreover, the iodine atom's potential for radiolabeling with radioisotopes of iodine makes this compound invaluable in the field of medical imaging and targeted therapy. By synthesizing peptides containing this iodinated amino acid and then introducing radioactive iodine, researchers can create diagnostic agents for tracking biological pathways or therapeutic agents for localized treatment. The availability of Boc-D-4-Iodophenylalanine at a competitive price facilitates its adoption in a wide range of research and development projects aiming to improve healthcare outcomes.

NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to scientific innovation by supplying high-quality Boc-D-4-Iodophenylalanine. Our commitment to excellence in chemical synthesis ensures that our clients receive products that meet the highest standards, enabling them to achieve their research and development goals efficiently. For any inquiries regarding Boc-D-4-Iodophenylalanine, its properties, or its applications, our team is ready to assist.