The Chemistry Behind Gemcitabine: Understanding Key Intermediates
The development of effective cancer therapies often hinges on intricate chemical synthesis pathways, where each intermediate plays a crucial role. For Gemcitabine, a widely recognized chemotherapeutic agent, understanding its key intermediates is fundamental. One such vital compound is 2-Deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate (CAS: 122111-01-7), a compound that embodies the complexity and precision required in pharmaceutical manufacturing.
Gemcitabine, known for its antimetabolite properties, is synthesized through a series of chemical transformations, and 2-Deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate serves as a critical precursor. Its chemical name itself hints at its structure: a pentofuranose ring with difluoro substituents and dibenzoate ester groups. This specific structure is designed to facilitate the subsequent steps in the Gemcitabine synthesis, ultimately leading to the formation of the active drug. The high purity of this intermediate, often specified as ≥99.0%, is non-negotiable for pharmaceutical applications, as impurities can lead to side products or affect the stability and efficacy of the final drug.
The physical characteristics of 2-Deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate, such as its typical appearance as a white to off-white crystalline powder, are important quality control parameters. Its melting point, generally reported between 117-119°C, provides another benchmark for purity. For researchers and manufacturers in the field of pharmaceutical intermediates, ensuring the consistent supply of such compounds is essential. The global demand for Gemcitabine means there is a constant need for reliable sources of its high-quality intermediates. This demand drives innovation in synthesis and purification techniques within the fine chemical sector.
NINGBO INNO PHARMCHEM CO., LTD. is dedicated to meeting this demand by offering top-tier 2-Deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate. We understand the vital role this chemical plays in the healthcare industry and are committed to upholding the highest standards in its production and supply. Our focus on quality assurance ensures that our clients receive intermediates that are not only chemically precise but also manufactured with the utmost care. By partnering with NINGBO INNO PHARMCHEM CO., LTD., pharmaceutical companies can strengthen their supply chain and confidently advance their research and manufacturing of critical cancer treatments, underscoring the importance of trusted relationships in the pharmaceutical intermediates market.
Perspectives & Insights
Future Origin 2025
“We understand the vital role this chemical plays in the healthcare industry and are committed to upholding the highest standards in its production and supply.”
Core Analyst 01
“Our focus on quality assurance ensures that our clients receive intermediates that are not only chemically precise but also manufactured with the utmost care.”
Silicon Seeker One
“, pharmaceutical companies can strengthen their supply chain and confidently advance their research and manufacturing of critical cancer treatments, underscoring the importance of trusted relationships in the pharmaceutical intermediates market.”