In the dynamic landscape of pharmaceutical research and development, specific chemical compounds emerge as cornerstones, enabling breakthroughs in medicine. One such indispensable compound is 4-Bromo-2-fluoropyridine, identified by its CAS number 128071-98-7. This article, brought to you by NINGBO INNO PHARMCHEM CO.,LTD., delves into the multifaceted importance of this pyridine derivative in modern synthesis.

4-Bromo-2-fluoropyridine is a highly sought-after pharmaceutical intermediate due to its unique molecular structure and reactivity. Its chemical formula, C5H3BrFN, and a molecular weight of approximately 175.99 g/mol, contribute to its efficacy in complex organic transformations. As a colorless to light yellow liquid, it presents a consistent and reliable form for laboratory and industrial applications. The compound's density, around 1.7 g/cm³, and a flash point of approximately 72°C are critical parameters for safe handling and storage, underscoring the need for adherence to recommended guidelines.

The primary application of 4-Bromo-2-fluoropyridine lies in its role as a building block for Active Pharmaceutical Ingredients (APIs). Its halogen substituents, bromine and fluorine, are strategically positioned to facilitate selective chemical reactions, particularly cross-coupling reactions like the Suzuki-Miyaura coupling. This process is fundamental in constructing carbon-carbon bonds, a vital step in assembling complex drug molecules. For instance, it is instrumental in the preparation of isoquinolinone derivatives, which have shown promise in treating diseases associated with poly(ADP-ribose)polymerase-1 (PARP-1).

The versatility of 4-Bromo-2-fluoropyridine extends to its use in creating a wide array of heterocyclic compounds, which are prevalent in many therapeutic agents. Researchers value its ability to introduce specific functional groups and structural motifs, thereby tailoring the properties of potential drug candidates. Understanding the precise chemical properties of 4-Bromo-2-fluoropyridine is paramount for optimizing synthetic yields and purity.

When considering the procurement of such critical intermediates, the global supply chain plays a significant role. China has established itself as a powerhouse in the fine chemical industry, offering cost-effective production without compromising on quality. Sourcing from reputable fine chemical manufacturers in China ensures access to high-purity materials like 4-Bromo-2-fluoropyridine, which are essential for meeting stringent pharmaceutical standards. The efficiency and scalability of Chinese manufacturers make them ideal partners for companies of all sizes, from research institutions to large-scale pharmaceutical production facilities.

Effective handling and storage of halogenated pyridines like 4-Bromo-2-fluoropyridine are crucial to maintain their stability and reactivity. Storage in tightly closed containers in a cool, dry environment, away from direct sunlight and incompatible materials, is recommended. Adhering to these practices, often detailed in supplier datasheets, helps preserve the compound's integrity for its intended applications.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to supporting the advancement of pharmaceutical science by providing high-quality chemical intermediates. Our expertise in chemical synthesis and supply chain management ensures that researchers and manufacturers have access to the critical compounds they need to drive innovation. Whether you are exploring new synthetic routes or scaling up production, 4-Bromo-2-fluoropyridine is a key component that can contribute significantly to your project’s success.