The Importance of Pharmaceutical Intermediates: A Case Study of Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate
The intricate process of developing and manufacturing pharmaceuticals relies heavily on a robust supply of high-quality chemical intermediates. Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate, identified by its CAS number 147118-39-6, is a paramount example of such a crucial intermediate. Its pivotal role in the chemical synthesis of Rosuvastatin, a leading drug in the HMG-CoA reductase inhibitor class, underscores its importance in modern healthcare and the pharmaceutical industry.
Rosuvastatin is a critical medication for managing hypercholesterolemia, aimed at reducing cholesterol levels and thus lowering the risk of cardiovascular events. The effective and safe production of Rosuvastatin is directly dependent on the purity and structural integrity of its precursors. Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate serves as a sophisticated building block in this synthesis. Its specific chemical structure ensures that the subsequent reactions proceed efficiently, leading to the formation of the desired active pharmaceutical ingredient with high fidelity.
As a fine chemical, this intermediate is subject to rigorous quality control measures. Manufacturers must ensure exceptional purity, often above 99%, to comply with strict pharmaceutical regulations. The chemical synthesis of Rosuvastatin, like many other complex drug molecules, requires a reliable supply of intermediates that meet these exacting standards. This is where specialized chemical suppliers play a vital role. NINGBO INNO PHARMCHEM CO., LTD. is a company that has established a reputation for providing high-quality pharmaceutical intermediates, including CAS 147118-39-6, to the global market.
For pharmaceutical companies, selecting a dependable supplier for critical intermediates like Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate is a strategic decision. Factors such as product consistency, timely delivery, comprehensive documentation, and adherence to safety and regulatory standards are paramount. NINGBO INNO PHARMCHEM CO., LTD. strives to meet these demands, supporting the continuity and reliability of pharmaceutical manufacturing operations worldwide.
In conclusion, the importance of pharmaceutical intermediates cannot be overstated. Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate (CAS 147118-39-6) serves as a compelling case study, illustrating how specialized fine chemicals, sourced from reputable providers like NINGBO INNO PHARMCHEM CO., LTD., are fundamental to the production of essential medicines that significantly contribute to public health.
Perspectives & Insights
Alpha Spark Labs
“Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate, identified by its CAS number 147118-39-6, is a paramount example of such a crucial intermediate.”
Future Pioneer 88
“Its pivotal role in the chemical synthesis of Rosuvastatin, a leading drug in the HMG-CoA reductase inhibitor class, underscores its importance in modern healthcare and the pharmaceutical industry.”
Core Explorer Pro
“Rosuvastatin is a critical medication for managing hypercholesterolemia, aimed at reducing cholesterol levels and thus lowering the risk of cardiovascular events.”