In the intricate world of peptide synthesis, precision and control are paramount. N-alpha, N-im-bis-Boc-L-histidine, commonly known as Boc-His(Boc)-OH and identified by CAS number 20866-46-0, stands as a cornerstone reagent for researchers and manufacturers alike. Its unique structure, featuring tert-butoxycarbonyl (Boc) protecting groups on both the alpha-amino and imidazole nitrogen, addresses critical challenges in building complex peptide chains.

The primary function of these Boc groups is to temporarily block reactive sites on the histidine residue, preventing them from participating in unwanted side reactions during the coupling process. This selective protection is vital for both Solid-Phase Peptide Synthesis (SPPS) and solution-phase methodologies. Without adequate protection, the imidazole ring of histidine can undergo undesirable acylation or alkylation, leading to impure products and reduced yields. The use of Boc-His(Boc)-OH ensures that the histidine residue is incorporated into the growing peptide chain only at the desired point, maintaining regioselectivity and structural integrity.

When sourcing this essential chemical, understanding market dynamics is key. For those looking to buy Boc-His(Boc)-OH online, it is important to partner with reliable suppliers who can guarantee high purity and consistent quality. The availability of N-alpha, N-im-bis-Boc-L-histidine from reputable suppliers directly impacts the success of research and development projects, especially in the pharmaceutical sector where peptide-based drugs are increasingly important. Many companies offer this product, catering to various needs from small-scale research to bulk manufacturing, making it accessible for diverse applications.

The demand for protected histidine derivatives for peptide synthesis continues to grow as the field of peptide therapeutics expands. NINGBO INNO PHARMCHEM CO.,LTD. recognizes the significance of high-quality building blocks like Boc-His-OH CAS 20866-46-0. By ensuring a consistent supply of this meticulously protected amino acid, NINGBO INNO PHARMCHEM CO.,LTD. supports advancements in drug discovery, diagnostics, and various biochemical research applications. Researchers and developers can trust the quality and purity of the products sourced from established manufacturers to achieve accurate and efficient peptide synthesis outcomes.