NINGBO INNO PHARMCHEM CO.,LTD. is proud to present a detailed look into a crucial component of modern pharmaceutical development: 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride (CAS 256499-19-1). This compound plays an indispensable role as a key intermediate in the synthesis of Riociguat, a groundbreaking medication used to treat pulmonary hypertension. Understanding the significance of such intermediates is vital for anyone involved in the pharmaceutical supply chain, from researchers to manufacturers.

Pulmonary hypertension is a serious condition characterized by high blood pressure in the pulmonary arteries. Riociguat, the final product derived from our intermediate, is a potent oral stimulator of soluble guanylate cyclase (sGC). By stimulating sGC, Riociguat enhances the effects of nitric oxide (NO), leading to vasodilation and reduced blood pressure in the pulmonary arteries, thereby alleviating symptoms and improving the quality of life for patients.

The chemical synthesis of Riociguat involves multiple complex steps, and the quality of each intermediate directly impacts the purity and efficacy of the final Active Pharmaceutical Ingredient (API). Our 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride boasts a high assay of u226598.0% and appears as a white solid, indicative of its stringent purity standards. These attributes are paramount for pharmaceutical applications where consistency and reliability are non-negotiable.

As a leading pharmaceutical intermediate manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing materials that meet the exacting requirements of the pharmaceutical industry. The reliable supply of intermediates like CAS 256499-19-1 is crucial for ensuring that patients have access to life-changing medications. Our expertise in producing these complex organic molecules enables pharmaceutical companies to streamline their manufacturing processes and accelerate drug development.

The pyrazolo[3,4-b]pyridine derivatives, to which this intermediate belongs, are a class of compounds that have shown significant promise in medicinal chemistry due to their diverse biological activities. The specific structure of 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride, with its fluorophenylmethyl substituent and pyrazolopyridine core, is optimized for its role in the Riociguat synthesis pathway. This strategic chemical design ensures efficient conversion and high yields in subsequent reaction steps.

For companies looking to buy 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source. We understand the critical nature of the Riociguat intermediate synthesis and are dedicated to supporting our clients with high-quality products and technical expertise. Our role as a supplier extends beyond mere provision; we aim to be a partner in advancing healthcare solutions.

In conclusion, the importance of 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride in the pharmaceutical industry cannot be overstated. It is a cornerstone for the production of Riociguat, offering a vital link in the chain of treatments for pulmonary hypertension. NINGBO INNO PHARMCHEM CO.,LTD. is committed to excellence in providing this and other essential chemical intermediates.