The ongoing battle against cancer has driven significant advancements in targeted therapies, and chemical intermediates play a critical role in these breakthroughs. (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, identified by CAS number 1022150-12-4, is a prime example of such a vital compound, central to the development of effective cancer therapeutics.

NINGBO INNO PHARMCHEM CO.,LTD. highlights that this chemical intermediate is a key component in the synthesis of Ibrutinib, a powerful Bruton's tyrosine kinase (Btk) inhibitor. Btk is a crucial enzyme involved in cell signaling pathways that regulate the growth and survival of various cancer cells, particularly B-cell malignancies like chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). By inhibiting Btk, Ibrutinib disrupts these pathways, leading to reduced cancer cell proliferation and survival.

The meticulous Ibrutinib intermediate synthesis process demands a high-purity precursor like (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Its specific chemical structure, with a molecular formula of C22H22N6O and a molecular weight of 386.45, allows for precise chemical modifications to create the final active pharmaceutical ingredient. As a Bruton's tyrosine kinase inhibitor precursor, its role is fundamental in enabling the therapeutic action of Ibrutinib.

The availability of this fine chemical for pharmaceutical R&D empowers researchers to explore further applications and develop next-generation inhibitors. The pyrazolo-pyrimidine derivative class of compounds is of significant interest in oncology due to its versatile structure, which can be modified to target various kinases implicated in cancer. This makes (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine a valuable asset in the ongoing quest for innovative cancer treatments.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the pharmaceutical industry's efforts in cancer therapy development. By ensuring a consistent and high-quality supply of this critical intermediate, we facilitate the research and manufacturing processes that bring life-saving medications to patients. Reliable API intermediate sourcing is the bedrock upon which successful drug development is built, and this compound is a perfect illustration of that principle.