NINGBO INNO PHARMCHEM CO.,LTD. is proud to present an in-depth look at 6-O-Benzylguanine (CAS 19916-73-5), a compound of significant interest in the field of oncology and pharmaceutical research. This molecule, a synthetic derivative of guanine, is primarily recognized for its potent ability to inhibit DNA repair mechanisms within cells. Understanding how to effectively buy 6-O-Benzylguanine is often the first step for researchers delving into this area.

The core function of 6-O-Benzylguanine lies in its classification as an O6-Benzylguanine DNA repair inhibitor. It operates as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase (AGT). AGT is a critical enzyme responsible for repairing specific types of DNA damage, particularly alkylation damage. By irreversibly binding to and inactivating AGT, 6-O-Benzylguanine effectively prevents the repair of damaged DNA. This mechanism is particularly relevant in cancer therapy, where the aim is often to induce lethal DNA damage in rapidly dividing cancer cells.

Historically, 6-O-Benzylguanine was explored clinically in combination with alkylating agents, such as temozolomide, for the treatment of glioblastoma. The rationale was that by inhibiting DNA repair, the cytotoxic effects of temozolomide would be enhanced. However, clinical trials revealed that while potent, the combination sometimes led to excessive toxicity without a significant increase in therapeutic benefit, leading to a re-evaluation of its direct clinical application in that specific context. Despite this, the compound remains a vital tool in the research laboratory.

Researchers seeking to advance cancer treatments or study the intricacies of DNA repair often look for reliable suppliers to purchase 6-O-Benzylguanine. Its role as a guanine derivative antineoplastic agent continues to be investigated for its potential in novel therapeutic strategies. The precise mechanism by which it acts as an O6-alkylguanine-DNA alkyltransferase suicide inhibitor provides a target for developing new drugs that could sensitize cancer cells to chemotherapy or radiation.

In summary, 6-O-Benzylguanine is more than just a chemical compound; it is a key enabler of scientific discovery in the fight against cancer. Its ability to block essential cellular repair processes makes it an invaluable asset for researchers exploring new avenues in oncology. The continuous research into this O6-Benzylguanine DNA repair inhibitor highlights its enduring significance in the pharmaceutical landscape.