NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing researchers with the essential tools for advancing scientific understanding. Among these, 6-O-Benzylguanine (CAS 19916-73-5) holds a special place, particularly within the realm of cancer biology. For those in the research community asking how to buy 6-O-Benzylguanine, we offer a reliable source for this vital compound.

The significance of 6-O-Benzylguanine in cancer biology research stems from its potent activity as an O6-Benzylguanine DNA repair inhibitor. It functions by acting as a suicide inhibitor for the enzyme O6-alkylguanine-DNA alkyltransferase (AGT). AGT is a key player in the cellular defense against DNA damage, specifically the repair of O6-alkylguanine adducts, which are often introduced by chemotherapeutic agents. By inactivating AGT, 6-O-Benzylguanine prevents the repair of such adducts, thereby potentiating the cytotoxic effects of DNA-damaging drugs.

This mechanism makes 6-O-Benzylguanine a valuable research tool for studying the consequences of unrepaired DNA damage in cancer cells. Researchers use it to investigate cell cycle arrest, apoptosis, and the overall response of tumors to genotoxic stress. As a guanine derivative antineoplastic agent, it provides a means to explore the sensitivity of different cancer types to DNA repair inhibition, informing the development of personalized medicine approaches.

The historical exploration of 6-O-Benzylguanine in clinical settings, although facing challenges, has provided invaluable insights into the complex interplay between DNA repair enzymes and cancer therapeutics. This knowledge continues to guide current research. Scientists aiming to understand resistance mechanisms to alkylating agents or to develop novel combination therapies often seek to purchase 6-O-Benzylguanine for their studies.

In conclusion, 6-O-Benzylguanine is an indispensable compound for cancer biology research. Its well-defined function as an O6-alkylguanine-DNA alkyltransferase suicide inhibitor allows for targeted investigations into DNA repair, cell survival, and therapeutic efficacy. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting these crucial research efforts by supplying high-purity 6-O-Benzylguanine.