The Significance of 2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine in Drug Development
The pharmaceutical industry is in constant pursuit of innovative treatments for complex diseases. Central to this endeavor is the precise synthesis of Active Pharmaceutical Ingredients (APIs), which often begins with the meticulous preparation of specific chemical intermediates. Among these essential building blocks, 2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine, identified by its CAS Number 90213-66-4, holds significant importance, particularly in the development of JAK inhibitors.
This compound, typically appearing as an off-white to yellow powder, serves as a foundational element in the synthesis of Tofacitinib Citrate, a widely recognized JAK inhibitor used for treating rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. The presence of chlorine atoms at the 2 and 4 positions of the pyrrolo[2,3-d]pyrimidine ring makes it a versatile precursor, allowing for subsequent chemical modifications essential for constructing the final drug molecule. The synthesis of Tofacitinib intermediate CAS 90213-66-4 is a complex process that requires specialized knowledge and advanced chemical techniques.
The role of NINGBO INNO PHARMCHEM CO.,LTD. in providing high-quality pharmaceutical intermediates like this is critical for the drug development pipeline. Ensuring the purity and consistency of such compounds is not merely a quality control measure but a fundamental requirement for the safety and efficacy of the final API. The rigorous standards applied in the chemical synthesis research of these compounds guarantee that they meet the exacting demands of pharmaceutical manufacturing.
The strategic importance of 2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine extends to its use in developing other related compounds and exploring novel therapeutic avenues. As research into JAK inhibitors and other signaling pathway modulators continues, the demand for reliable suppliers capable of facilitating the 'buy Tofacitinib intermediate online' requests will persist. The availability of such essential chemicals at competitive prices is vital for the economic feasibility of bringing new treatments to market.
Understanding the chemical properties and reactivity of this intermediate is key for chemists and researchers. Its classification as a fine chemical intermediate underscores its specialized nature and its critical role in bridging basic chemical synthesis with complex API production. The continued exploration of new synthetic routes and process optimizations for this compound ensures its ongoing relevance in the evolving field of medicinal chemistry.
In conclusion, 2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine is more than just a chemical compound; it is an enabler of therapeutic innovation. Its precise role in the synthesis of Tofacitinib and its potential in future drug development highlight the indispensable nature of high-quality chemical intermediates in the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to this vital sector by providing essential building blocks for groundbreaking medicines.
Perspectives & Insights
Bio Analyst 88
“Central to this endeavor is the precise synthesis of Active Pharmaceutical Ingredients (APIs), which often begins with the meticulous preparation of specific chemical intermediates.”
Nano Seeker Pro
“Among these essential building blocks, 2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine, identified by its CAS Number 90213-66-4, holds significant importance, particularly in the development of JAK inhibitors.”
Data Reader 7
“This compound, typically appearing as an off-white to yellow powder, serves as a foundational element in the synthesis of Tofacitinib Citrate, a widely recognized JAK inhibitor used for treating rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.”