For synthetic organic chemists, understanding the preparation and reactivity of key building blocks is fundamental to successful research. NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing such essential materials, including 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine (CAS 41102-25-4). This compound's unique structure, featuring a thieno[3,2-d]pyrimidine core with strategically placed halogen atoms, imbues it with significant reactivity, making it a valuable intermediate for creating complex molecular architectures.

The synthesis of 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine often involves a sequence of carefully controlled reactions. Typically, the thieno[3,2-d]pyrimidine scaffold is first synthesized, after which halogenation steps are performed. Bromination at the 7-position can be achieved using reagents like N-bromosuccinimide (NBS) in inert solvents, while chlorination at the 2 and 4 positions often employs agents such as phosphorus oxychloride (POCl₃). Optimizing these processes is crucial. For instance, maintaining anhydrous conditions and using appropriate catalysts can significantly improve the yield and regioselectivity of the bromination and chlorination steps, ensuring high purity of the final product. The careful control of reaction parameters is key to efficient preparation of CAS 41102-25-4.

The reactivity of 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine lies primarily in its halogen substituents, which are excellent leaving groups for various cross-coupling reactions. The bromine at the 7-position is particularly amenable to Suzuki, Stille, and Sonogashira couplings, allowing for the introduction of diverse carbon-based fragments. Similarly, the chlorine atoms can participate in nucleophilic substitution reactions or Buchwald-Hartwig aminations. This versatile reactivity profile makes it a highly sought-after intermediate in medicinal chemistry, enabling the synthesis of libraries of compounds for drug screening. Exploring the structure-activity relationship of thieno[3,2-d]pyrimidine derivatives highlights how these modifications impact biological outcomes.

At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical importance of reliable and high-quality synthetic intermediates. Our expertise ensures that 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine is produced to the highest standards, facilitating groundbreaking research in organic synthesis and medicinal chemistry. Researchers can confidently utilize our CAS 41102-25-4 to explore new chemical spaces and develop innovative solutions for various applications, from pharmaceuticals to materials science.