Oroxylin A, scientifically identified as 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl (CAS 480-11-5), is a remarkable natural compound garnering significant attention in the scientific community. As a potent flavonoid, its therapeutic potential, particularly its anticancer properties, is a subject of extensive research. This article delves into the findings surrounding Oroxylin A's ability to combat cancer cells, offering insights valuable for researchers and pharmaceutical developers.

One of the key mechanisms through which Oroxylin A exerts its effects is by modulating crucial cellular pathways. Studies indicate that Oroxylin A can suppress the MDM2-mediated degradation of p53, a critical tumor suppressor protein. This action helps restore normal p53 function, which is vital for preventing uncontrolled cell growth. Furthermore, Oroxylin A has been shown to inhibit HIF-1α expression and stability, particularly under hypoxic conditions. HIF-1α plays a significant role in tumor progression and angiogenesis, making its inhibition a promising strategy in cancer therapy. The compound also promotes the expression and activity of SOD2 (Superoxide Dismutase 2) by regulating the DNA-binding activity of FOXO3a, an enzyme essential for protecting cells from oxidative stress, which is often exacerbated in cancer environments.

The efficacy of Oroxylin A has also been demonstrated in vivo. Research has shown that Oroxylin A can inhibit tumor growth in models inoculated with human cancer cells. This preclinical evidence strongly supports its potential as an anticancer agent. For professionals in the pharmaceutical industry, understanding these mechanisms is crucial for developing new therapeutic strategies. If you are looking to buy Oroxylin A for your research, ensuring high purity and reliable sourcing is paramount. Several suppliers offer Oroxylin A with purity levels of 98% and above, making it accessible for advanced scientific applications.

Beyond its anticancer effects, Oroxylin A also finds applications in cosmetic formulations due to its inherent properties. Its natural origin and biological activity make it an attractive ingredient for high-end skincare products. The accessibility of Oroxylin A through online chemical suppliers, with various payment and shipping options, facilitates its widespread use. Whether for groundbreaking pharmaceutical research or innovative cosmetic development, Oroxylin A represents a compound with significant promise. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality compounds like Oroxylin A to advance scientific discovery.