NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of providing high-quality pharmaceutical intermediates that drive innovation in medical research. Among our key offerings is GTS-21 dihydrochloride, a compound gaining significant attention for its therapeutic potential. This article delves into the scientific underpinnings of GTS-21, focusing on its action as a selective alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist and its dual benefits in managing inflammation and enhancing cognitive functions.

The α7-nAChR is a critical component in various neurological and inflammatory pathways. GTS-21 dihydrochloride has demonstrated remarkable efficacy in modulating these pathways. In vitro studies have confirmed its ability to attenuate the production of pro-inflammatory cytokines, a crucial step in mitigating inflammatory responses. Furthermore, research indicates that GTS-21 can improve outcomes in models of sepsis, pancreatitis, and ischemia-reperfusion injury, highlighting its broad anti-inflammatory capabilities. The compound's mechanism involves regulating the JAK2-STAT3 pathway, which is instrumental in controlling cellular responses to inflammation.

Beyond its anti-inflammatory actions, GTS-21 dihydrochloride is recognized for its cognitive enhancing properties. By targeting the α7-nAChR, it plays a role in neurotransmission, which is vital for learning and memory. This makes it a compound of significant interest in the development of treatments for cognitive disorders. The precise action of GTS-21 on neuronal circuits offers a promising avenue for neuropharmacological research.

In vivo studies further substantiate the efficacy of GTS-21. In animal models of sepsis, the administration of GTS-21 dihydrochloride led to significant improvements, including ameliorated gastrointestinal motility, lower levels of systemic and colonic inflammatory markers like IL-6, and decreased colonic permeability. These findings underscore the compound's systemic benefits in combating the damaging effects of sepsis. The research also observed that GTS-21 was beneficial even in specific genetic models, showcasing its robust therapeutic potential.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying researchers and pharmaceutical companies with premium-grade GTS-21 dihydrochloride. We understand the importance of purity and consistency in advancing scientific discovery. Our commitment is to provide a reliable source for this potent pharmaceutical intermediate, enabling groundbreaking research in areas of inflammation control and cognitive enhancement. For those looking to buy GTS-21 dihydrochloride, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing and fast delivery, ensuring your research progresses without interruption.