The chemical industry thrives on the precise synthesis of complex molecules, often relying on specialized intermediates to achieve desired structures and functionalities. Among these vital compounds, 4-Methoxybenzyl Bromide, identified by its CAS number 2746-25-0, holds significant importance, particularly within the pharmaceutical sector. Its primary claim to fame is its indispensable role as a precursor in the synthesis of Tacrolimus, a vital immunosuppressant medication.

Delving into the specifics, 4-Methoxybenzyl Bromide is described as a colorless to light yellow liquid. Its chemical specifications are rigorous, with an assay requirement of ≥98.0%, ensuring a high degree of purity crucial for pharmaceutical applications. The compound's molecular formula is C8H9BrO, and its molecular weight is 201.061. Key physical properties, such as a boiling point of approximately 241.6 °C and a flash point of around 95.6 °C, are critical for chemists to consider when planning reaction conditions and ensuring safe laboratory practices. These characteristics contribute to its utility in various chemical transformations.

The principal application of 4-Methoxybenzyl Bromide is as a direct intermediate in the manufacturing process of Tacrolimus. Tacrolimus is a critical drug used to prevent the rejection of transplanted organs such as kidneys and livers, and it is also employed in managing severe cases of atopic dermatitis. The complex structure of Tacrolimus necessitates a carefully orchestrated series of chemical reactions, and 4-Methoxybenzyl Bromide is strategically incorporated at a specific step to build the molecular framework. The reliable sourcing of this high-purity chemical intermediate is, therefore, fundamental for pharmaceutical companies engaged in the production of this life-saving drug.

For those in the field of chemical research and development, understanding the properties of CAS 2746-25-0 allows for the optimization of synthetic routes and the exploration of new applications. Its reactivity, stemming from the presence of the benzylic bromide, makes it a versatile reagent in various organic transformations. This versatility is key to its value as a building block in the creation of complex organic molecules, supporting the broader goals of API Synthesis Building Blocks development.

In conclusion, the significance of 4-Methoxybenzyl Bromide, identified by CAS 2746-25-0, cannot be overstated in the context of pharmaceutical synthesis. Its role as a high-purity intermediate for Tacrolimus underscores its importance in modern medicine. By providing reliable access to such critical chemical components, suppliers empower researchers and manufacturers to advance the development and production of essential pharmaceuticals.