5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, identified by its CAS number 881674-56-2, is a complex organic compound that plays a significant role in the pharmaceutical industry. Its chemical structure, C11H8FNO, and molecular weight of 189.19, provide the foundation for its utility as a crucial intermediate in the synthesis of potent drugs. This article explores its chemical properties and its vital applications, particularly in the development of potassium-competitive acid blockers (P-CABs).

The compound is characterized by several key properties. It typically presents as a light brown to brown solid with a density around 1.270 ± 0.06 g/cm³ and a predicted boiling point of 370.6 ± 32.0 °C. Its solubility in common organic solvents like chloroform, DMSO, and methanol, albeit mild, is important for its processing in synthesis reactions. These physical and chemical characteristics are essential for its handling and integration into various chemical pathways. Furthermore, its role as a pharmaceutical intermediate means that consistency in these properties, ensured by meticulous manufacturing, is highly valued.

The primary application of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is its function as an intermediate in the synthesis of Vonoprazan fumarate. This drug is a significant advancement in treating acid-related diseases, offering a more effective alternative to traditional proton pump inhibitors. The synthesis pathway relies on the precise reactivity of this pyrrole derivative. The ability to efficiently synthesize this intermediate, as evidenced by various patented preparation methods, is a testament to advancements in organic chemistry and process engineering. For companies looking for a reliable 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturer, exploring options like NINGBO INNO PHARMCHEM CO.,LTD. can provide access to expertise in fine chemical synthesis.

The importance of such intermediates extends to the broader field of drug discovery. As researchers continue to explore new therapeutic targets and develop novel drug candidates, compounds like 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde become foundational elements. The reliable supply of this chemical, backed by strong supplier relationships, ensures that innovation in the pharmaceutical sector can continue uninterrupted. Understanding the chemical properties and application potential of such compounds is key for anyone involved in the research, development, or manufacturing of advanced pharmaceuticals.