2-Chlorophenylacetic Acid (CAS 2444-36-2) is more than just a chemical compound; it's a testament to the power of organic synthesis and a cornerstone for numerous industrial applications. Understanding its chemical properties and synthesis methods is key to appreciating its value, particularly in the pharmaceutical and agrochemical sectors.

Chemically, 2-Chlorophenylacetic Acid possesses the molecular formula C8H7ClO2 and a molecular weight of approximately 170.59 g/mol. It typically presents as a white crystalline solid, with a melting point range of 92-95°C. This specific crystalline structure and melting point are critical indicators of its purity and suitability for downstream reactions. Its solubility characteristics are also noteworthy: while sparingly soluble in water, it dissolves readily in common organic solvents such as ethanol and acetone. This solubility profile is advantageous for many chemical processes, allowing for easier manipulation and reaction in various solvent systems.

The synthesis of 2-Chlorophenylacetic Acid often involves key organic reactions that transform precursor molecules into this valuable intermediate. Common routes include the hydrolysis of 2-chlorobenzyl cyanide or reactions starting from 2-chlorobenzyl chloride. These methods are carefully controlled to ensure high yields and purity, which are essential for its subsequent use in sensitive applications like pharmaceutical manufacturing. The purity of the final product is typically above 99%, often verified through Gas Chromatography (GC), with strict limits on moisture content to prevent interference in reactions.

The presence of the chlorine atom at the ortho position on the phenyl ring significantly influences the reactivity of 2-Chlorophenylacetic Acid. This chloro-substitution enhances its electrophilic character, making it a potent intermediate for complex organic transformations. It readily participates in reactions such as esterification, amidation, and nucleophilic substitution. These reactions are fundamental to building larger, more complex molecules required for pharmaceutical APIs and agrochemical actives. The predictability and efficiency of these reactions are why 2-Chlorophenylacetic Acid is a preferred intermediate in many synthesis pathways.

For industries that rely on precise chemical synthesis, sourcing high-quality 2-Chlorophenylacetic Acid is crucial. NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier committed to providing this vital intermediate with exceptional purity and consistent quality. Our expertise in chemical manufacturing ensures that our product meets rigorous industry standards, supporting the success of your research and production endeavors. Understanding the chemical journey of 2-Chlorophenylacetic Acid from synthesis to application reveals its profound impact on modern industries.