Chloromethyl Isopropyl Carbonate (CMIC), identified by CAS No. 35180-01-9, is a chemical compound that plays a vital role in specialized industrial and pharmaceutical applications. Characterized by its appearance as a clear, colorless to pale yellow liquid, CMIC possesses a mild ethereal odor and is miscible with common organic solvents like methanol and dimethylformamide, but largely insoluble in water. These physical and chemical properties are crucial for its effective use as a pharmaceutical intermediate and in organic synthesis.

The primary application driving the demand for CMIC is its critical function as an intermediate in the manufacturing of Tenofovir. Tenofovir, a nucleoside reverse transcriptase inhibitor, is a vital component in antiretroviral therapy for HIV/AIDS and is also used in the treatment of chronic Hepatitis B. The synthesis of Tenofovir involves specific chemical reactions where CMIC's reactive chloromethyl group and carbonate structure are leveraged to build the drug's active moiety. This makes CMIC an indispensable raw material for pharmaceutical companies focused on antiviral drug development.

Ensuring the quality of CMIC is paramount, especially given its pharmaceutical end-use. NINGBO INNO PHARMCHEM CO.,LTD., as a reputable manufacturer, adheres to stringent quality assurance protocols. This includes maintaining high purity levels, typically 99% or more as verified by Gas Chromatography (GC). Furthermore, critical parameters such as moisture content (≤0.5% by Karl Fischer titration) and chloride content (≤0.3%) are meticulously controlled. Residual solvents are also managed according to ICH Q3C guidelines, ensuring the absence of harmful contaminants. These rigorous quality checks are fundamental to guaranteeing that the CMIC supplied meets the demanding standards of the pharmaceutical industry.

The broader applications of CMIC extend to general organic synthesis, where it serves as a valuable building block for creating various organic compounds. Its ability to undergo nucleophilic substitution reactions makes it a versatile tool for synthetic chemists. The consistent availability of high-quality CMIC from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. supports research and development efforts across multiple chemical disciplines, contributing to innovation and the creation of new chemical entities. By focusing on quality and consistent supply, NINGBO INNO PHARMCHEM CO.,LTD. solidifies its position as a key player in the global supply chain for this essential chemical intermediate.