Ningbo Inno Pharmchem Co., Ltd. is at the forefront of providing advanced chemical intermediates for critical therapeutic areas. Today, we delve into the science of CRTh2 receptor antagonists, with a particular focus on SM04554, a compound that holds significant promise in treating inflammatory conditions such as asthma.

CRTh2, also known as the chemoattractant receptor-homologous expressed on Th2 cells, is a G protein-coupled receptor that plays a key role in the inflammatory response mediated by Th2 cells. Prostaglandin D2 (PGD2), a potent pro-inflammatory mediator, binds to CRTh2, triggering downstream signaling pathways that promote eosinophil recruitment and activation, as well as Th2 cell differentiation. This process is central to the pathophysiology of allergic asthma and other Th2-driven diseases.

SM04554 is a highly potent and selective CRTh2 receptor antagonist. Its ability to block the binding of PGD2 to CRTh2 effectively inhibits the inflammatory cascade. Studies have shown that SM04554 can significantly reduce eosinophilic airway inflammation in patients with persistent asthma, even those already on inhaled corticosteroid treatment. This offers a new therapeutic avenue for individuals with difficult-to-manage asthma. For researchers interested in this area, acquiring pharmaceutical grade SM04554 is crucial for accurate experimental outcomes.

The chemical compound SM04554 (CAS 1360540-81-3) is typically supplied as a white powder, with high purity levels exceeding 99%. Its availability as a research chemical SM04554 allows scientists to explore its full therapeutic potential. At Ningbo Inno Pharmchem Co., Ltd., we understand the importance of consistent quality and purity for these applications, ensuring our clients can rely on our products for their research endeavors.

Beyond asthma, CRTh2 antagonists like SM04554 are being investigated for their potential efficacy in other Th2-mediated inflammatory diseases, including atopic dermatitis, allergic rhinitis, and allergic conjunctivitis. The underlying mechanism of reducing eosinophilic inflammation suggests a broad applicability. Therefore, individuals looking to buy SM04554 raw powder may be doing so for a variety of research projects related to inflammatory diseases.

As the field of targeted therapy advances, the importance of compounds like SM04554, which offer specific mechanisms of action, becomes increasingly evident. Ningbo Inno Pharmchem Co., Ltd. is committed to facilitating these advancements by providing access to high-quality SM04554 and supporting the research community. We are continuously working to ensure that our supply of high purity SM04554 for sale meets the demanding standards of pharmaceutical research and development.

In summary, SM04554 stands out as a significant CRTh2 receptor antagonist with proven benefits in asthma management and potential applications in other inflammatory conditions. Ningbo Inno Pharmchem Co., Ltd. is proud to be a reliable supplier of this vital compound, contributing to the ongoing quest for effective treatments.

For inquiries regarding CAS 1360540-81-3 hair treatment or its use as an anti-inflammatory agent, please reach out to Ningbo Inno Pharmchem Co., Ltd.