As a leading supplier in the fine chemical sector, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality pharmaceutical intermediates. Among our key offerings is Domperidone Maleate (CAS: 99497-03-7), a compound with significant therapeutic applications in gastroenterology and beyond. This article aims to provide healthcare professionals with a detailed understanding of Domperidone Maleate, from its mechanism of action to its diverse clinical uses and safety profile.

Domperidone Maleate functions primarily as a dopamine antagonist. Its efficacy stems from its ability to block dopamine D2 and D3 receptors, particularly in the chemoreceptor trigger zone (CTZ) located outside the blood-brain barrier. This peripheral selectivity is crucial, as it minimizes central nervous system side effects that are common with other dopamine antagonists. This mechanism of action makes it highly effective in combating nausea and vomiting, a common symptom in various medical conditions and treatments.

Beyond its antiemetic properties, Domperidone Maleate is also recognized for its prokinetic effects. It enhances gastrointestinal motility by promoting the release of acetylcholine in the enteric nervous system, thereby facilitating the faster movement of food through the stomach and intestines. This makes it an indispensable agent in the management of gastroparesis, a condition characterized by delayed gastric emptying. Understanding the domperidone maleate uses for gastroparesis is key for effective treatment planning.

The typical domperidone maleate dosage for adults ranges from 10 to 20 mg, administered three to four times daily, ideally 15 to 30 minutes before meals. This dosage regimen ensures optimal absorption and therapeutic effect. It's important for healthcare providers to be aware of the specific domperidone maleate dosage for different indications to ensure patient safety and efficacy. While generally well-tolerated, potential side effects such as dry mouth, abdominal cramps, and headache can occur. More serious concerns, such as cardiac arrhythmias, are rare but necessitate careful patient selection and monitoring, particularly in those with pre-existing heart conditions or those taking interacting medications.

Domperidone maleate drug interactions are a critical consideration. Inhibitors of the CYP3A4 enzyme, such as ketoconazole and erythromycin, can significantly increase domperidone levels in the blood, raising the risk of adverse cardiac events. Therefore, concomitant use with such agents should be avoided or managed with extreme caution. Healthcare professionals must remain vigilant regarding these interactions to ensure patient safety.

Furthermore, Domperidone Maleate has garnered attention for its role in lactation support. While not its primary indication, it is sometimes prescribed off-label to help increase breast milk supply in breastfeeding mothers when other methods have proven insufficient. This application highlights the compound's multifaceted pharmacological profile. Exploring domperidone for lactation support requires careful assessment of the benefit-risk ratio for individual patients.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting pharmaceutical research and development by providing reliable and high-purity chemicals. Our expertise in producing Domperidone Maleate ensures that our clients receive a product that meets stringent quality standards. We encourage healthcare professionals to stay informed about the latest research and clinical guidelines concerning Domperidone Maleate to optimize patient care and outcomes.