NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing the life science community with high-quality reagents that drive innovation. Today, we focus on Fmoc-Lys-OH HCl (CAS 139262-23-0), a crucial protected amino acid derivative that underpins many advancements in peptide synthesis and related fields. Understanding its chemical properties and advantages is key to optimizing research outcomes.

The process of peptide synthesis, particularly solid-phase peptide synthesis (SPPS), relies on the controlled addition of amino acids. Fmoc-Lys-OH HCl plays a pivotal role in this process due to its Fmoc protection strategy. The 9-fluorenylmethoxycarbonyl (Fmoc) group is a base-labile protecting group for the alpha-amino function of amino acids. This strategy allows for selective deprotection using mild reagents like piperidine, which is a significant advantage over the acid-labile Boc (tert-butyloxycarbonyl) strategy, especially when working with sensitive molecules or incorporating complex modifications. The availability of Fmoc-Lys-OH HCl at competitive prices makes it a practical choice for researchers worldwide.

The chemical structure of Fmoc-Lys-OH HCl incorporates the essential amino acid lysine, which has a unique side chain featuring a terminal amino group. This side chain functionality is particularly valuable for further modifications after peptide assembly. The Fmoc protection ensures that the alpha-amino group is masked during coupling steps, preventing self-polymerization and ensuring that peptide bonds form only between the intended carboxyl and amino termini. When it's time to remove the Fmoc group, the resulting dibenzofulvene by-product is efficiently scavenged by the base. This methodical approach, facilitated by reliable reagents like Fmoc-Lys-OH HCl, is fundamental to achieving high yields and purity in synthesized peptides.

The applications of Fmoc-Lys-OH HCl are far-reaching. In pharmaceutical research, it's a critical intermediate for developing peptide-based drugs, which are increasingly being used to treat a variety of diseases. Lysine residues can be modified to attach targeting ligands, improve drug delivery, or enhance the stability of the therapeutic peptide. Its use in bioconjugation is also extensive, enabling the creation of antibody-drug conjugates (ADCs) or the labeling of peptides for diagnostic purposes. By linking peptides containing lysine to specific antibodies, researchers can target drug delivery to cancer cells, for instance. In protein engineering, modifying lysine residues can fine-tune protein function, stability, and interaction with other molecules, leading to the development of novel enzymes or therapeutic proteins.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying researchers with the highest quality Fmoc-Lys-OH HCl. Our rigorous quality control ensures that our product meets the demanding purity standards required for advanced peptide synthesis and pharmaceutical applications. By providing reliable access to this essential amino acid derivative, we empower scientists to push the boundaries of innovation in medicine and biotechnology. Trust NINGBO INNO PHARMCHEM CO.,LTD. for your critical research needs.