At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to supplying innovative chemical compounds that push the boundaries of scientific understanding. Today, we focus on GTS-21 dihydrochloride, a highly selective agonist for the alpha-7 nicotinic acetylcholine receptor (α7-nAChR). This compound's unique properties make it an invaluable tool for researchers investigating complex biological processes, particularly those related to inflammation and cognitive function.

The core of GTS-21's activity lies in its precise interaction with the α7-nAChR. This receptor subtype is widely distributed in the central and peripheral nervous systems, as well as in immune cells, suggesting its broad involvement in physiological and pathological processes. GTS-21 dihydrochloride acts by binding to and activating these receptors, mimicking the action of acetylcholine but with greater selectivity and potency for the α7 subtype.

One of the most significant applications of GTS-21 dihydrochloride is in the modulation of the inflammatory response. It has been shown to effectively attenuate the production of pro-inflammatory cytokines, such as TNF-alpha and IL-6, which are key mediators of inflammation. This action is particularly relevant in conditions characterized by chronic or acute inflammation, including sepsis and autoimmune diseases. Research indicates that GTS-21's anti-inflammatory effects are partly mediated through the JAK2-STAT3 signaling pathway, a critical cascade in cellular communication and immune regulation. By influencing this pathway, GTS-21 dihydrochloride offers a novel therapeutic strategy for controlling excessive inflammation.

Furthermore, the role of α7-nAChRs in cognitive processes, such as learning, memory, and attention, is well-established. GTS-21 dihydrochloride's ability to activate these receptors suggests its potential as a cognitive enhancer. By improving cholinergic neurotransmission, it can support neuronal function and potentially mitigate cognitive deficits associated with aging or neurodegenerative diseases. Researchers can purchase GTS-21 dihydrochloride from NINGBO INNO PHARMCHEM CO.,LTD. to explore these promising applications.

The comprehensive research supporting GTS-21 dihydrochloride underscores its importance as a pharmaceutical intermediate. NINGBO INNO PHARMCHEM CO.,LTD. ensures the highest purity and quality for our GTS-21 offerings, facilitating reliable and reproducible scientific outcomes. Whether you are interested in its anti-inflammatory properties or its potential for cognitive enhancement, GTS-21 dihydrochloride is a compound that warrants further investigation. We provide detailed product specifications and support for clients looking to buy this advanced chemical.