At NINGBO INNO PHARMCHEM CO., LTD., we appreciate that the effectiveness of Microcrystalline Cellulose (MCC) is highly dependent on selecting the correct grade. While chemically similar, different MCC grades possess distinct physical characteristics, such as particle size, bulk density, and moisture content, which significantly impact their performance in various formulations.

Understanding these variations is crucial for optimizing tabletability, flowability, and overall product quality. For example, grades like MCC 101 and 102 are widely used in direct compression tablet formulations due to their excellent compressibility. MCC 101, with finer particles, is often preferred for wet granulation, while MCC 102, with slightly larger particles, offers better flow for fine powders. MCC 200, characterized by larger particle sizes, is beneficial for improving API flow deficiencies and correcting flow issues.

Grades with lower moisture content, such as MCC 112 and 113, are particularly important when formulating moisture-sensitive active pharmaceutical ingredients. These grades minimize potential degradation and ensure product stability. Higher-density grades, like MCC 301 and 302, offer improved flowability and tablet weight uniformity, making them suitable for applications requiring precise dosing and efficient material handling.

The choice of MCC grade can directly influence critical material attributes (CMAs) of the final product, affecting tablet hardness, disintegration, and even drug release rates. Therefore, careful consideration of the specific application requirements—whether it's direct compression, wet granulation, spheronization, or handling moisture-sensitive materials—is essential when selecting an MCC grade. NINGBO INNO PHARMCHEM CO., LTD. provides a comprehensive range of MCC grades, supported by technical expertise to help you identify the optimal choice for your formulation needs, ensuring efficiency and success in your manufacturing processes.