o-Toluoyl Chloride (CAS 933-88-0) is a chemical compound that plays a significant role in various chemical processes, most notably as an intermediate in the synthesis of pharmaceuticals. This article aims to provide a detailed understanding of its properties, safety precautions, and a spectrum of its applications, offering valuable insights for chemists, researchers, and industry professionals.

Chemically known as 2-Methylbenzoyl Chloride, o-Toluoyl Chloride is an acyl halide derived from o-toluic acid. It typically appears as a clear, pale yellow to yellow to faintly pink liquid. Its chemical structure grants it significant reactivity, particularly as an acylating agent. This reactivity, however, also classifies it as a hazardous substance, requiring careful handling due to its corrosive nature and sensitivity to moisture. Proper storage, usually under an inert atmosphere and in tightly sealed containers, is crucial to maintain its quality and prevent decomposition.

The safety information associated with o-Toluoyl Chloride is extensive. Hazard symbols often indicate its corrosive properties, and it can cause severe skin burns and eye damage. Inhalation of vapors can also be irritating to the respiratory system. Therefore, when working with this compound, it is imperative to use appropriate personal protective equipment (PPE), including gloves, eye protection, and respiratory protection, in a well-ventilated area or fume hood. Understanding and adhering to the safety statements, such as 'Do not breathe vapor' and 'Wear suitable protective clothing,' is vital for preventing accidents.

The primary application of o-Toluoyl Chloride is its use as a key intermediate in the synthesis of Tolvaptan, a drug used to treat conditions like hyponatremia. The o-Toluoyl chloride synthesis pathways are well-documented, highlighting its importance in the pharmaceutical industry. Beyond this, its utility extends to general organic synthesis, where its acylating properties are employed to introduce the o-toluoyl moiety into various organic molecules. This makes it a valuable reagent for creating more complex chemical structures used in research and the development of new materials or drugs.

For those looking to procure this chemical, knowing that you can buy o-Toluoyl chloride online is beneficial, but selecting a reputable supplier is key. Factors such as product purity (often specified as ≥99.0%), packaging, and the availability of detailed technical data, including the CAS 933-88-0 chemical properties and safety data, are important considerations. The global network of o-Toluoyl chloride suppliers China and other regions contributes to its availability for various industrial and research purposes.

In summary, o-Toluoyl Chloride is a powerful chemical tool with critical applications, especially in pharmaceuticals. A thorough understanding of its chemical properties, strict adherence to safety protocols, and careful selection of suppliers are essential for harnessing its potential effectively and safely within the chemical and pharmaceutical landscape. Its role as a 2-methylbenzoyl chloride pharmaceutical intermediate solidifies its importance in modern chemistry.