Understanding PVP K90: A Deep Dive into its Properties and Uses as a Pharmaceutical Excipient by NINGBO INNO PHARMCHEM CO.,LTD.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing essential components for the pharmaceutical industry, and Polyvinylpyrrolidone K90 (PVP K90) is a cornerstone product in their portfolio. This comprehensive overview delves into the physical and chemical attributes of PVP K90 and elucidates its significant contributions to drug formulation, focusing on its functions as a dissolution enhancer and suspending agent.
Physically, PVP K90, as supplied by NINGBO INNO PHARMCHEM CO.,LTD., presents as a white to milky powder. It is characterized by being odorless or having a faint odor and is tasteless. A notable physical property is its hygroscopic nature, meaning it readily absorbs moisture from the atmosphere. This necessitates proper storage conditions, typically in cool, dry environments, to maintain its integrity. Chemically, it exhibits good solubility in water, ethanol, and isopropyl alcohol, and also dissolves in trichloromethane, although it is insoluble in acetone or ether. These solubility characteristics are crucial for its incorporation into various dosage forms.
The K-value of PVP K90, ranging between 81 and 97.2, indicates a relatively high molecular weight compared to other grades of PVP. This higher molecular weight contributes to its enhanced binding capabilities and viscosity-modifying properties, making it a preferred choice for specific pharmaceutical applications. When you buy PVP K90 powder from NINGBO INNO PHARMCHEM CO.,LTD., you are acquiring a product engineered for performance.
As a dissolution enhancer, NINGBO INNO PHARMCHEM CO.,LTD.'s PVP K90 is instrumental in improving the rate at which poorly soluble drugs dissolve. This is achieved through mechanisms like solid dispersion or complexation, where the PVP K90 polymer envelops the drug molecules, increasing their surface area available for dissolution. This property is critical for oral drug delivery, as faster dissolution generally leads to higher and more consistent absorption into the bloodstream.
Moreover, PVP K90 functions exceptionally well as a suspending agent. In liquid pharmaceutical preparations, it provides the necessary viscosity and particle suspension capabilities to prevent the settling of insoluble drug particles. This ensures dose uniformity throughout the product's shelf life. The stability offered by this pharmaceutical grade polyvinylpyrrolidone is a testament to its formulation advantages, making it a vital component for manufacturers seeking reliable suspending performance.
The commitment of NINGBO INNO PHARMCHEM CO.,LTD. to quality means that their PVP K90 meets rigorous pharmacopoeial standards, including USP and EP. These certifications assure users that the product is safe and effective for pharmaceutical use. For those looking for a dependable polyvinylpyrrolidone supplier, NINGBO INNO PHARMCHEM CO.,LTD. stands out for its consistent product quality and comprehensive technical support.
In summary, understanding the physical and chemical properties of PVP K90, alongside its critical roles as a dissolution enhancer and suspending agent, highlights why it is a sought-after excipient. NINGBO INNO PHARMCHEM CO.,LTD. provides a high-quality product that supports the development of advanced and effective pharmaceutical formulations.
Perspectives & Insights
Quantum Pioneer 24
“This higher molecular weight contributes to its enhanced binding capabilities and viscosity-modifying properties, making it a preferred choice for specific pharmaceutical applications.”
Bio Explorer X
“'s PVP K90 is instrumental in improving the rate at which poorly soluble drugs dissolve.”
Nano Catalyst AI
“This is achieved through mechanisms like solid dispersion or complexation, where the PVP K90 polymer envelops the drug molecules, increasing their surface area available for dissolution.”