Ningbo Inno Pharmchem Co., Ltd. offers a deep dive into the chemical profile of 1-Boc-4-(2-chloroethyl)piperazine (CAS: 208167-83-3), a critical intermediate in synthetic organic chemistry. Understanding its chemical identity, synthesis, and reactivity is essential for its effective utilization in research and development.

The compound's nomenclature, including synonyms like tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate and N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE, reflects its structural components. The core is a piperazine ring, functionalized with a Boc protecting group on one nitrogen and a 2-chloroethyl chain on the other. The Boc group is a common protecting group in peptide synthesis and organic chemistry, easily introduced and removed. Its role is to temporarily block the reactivity of the nitrogen atom, allowing transformations elsewhere in the molecule. The 2-chloroethyl group, meanwhile, is an alkyl halide that can undergo nucleophilic substitution reactions, making it a valuable electrophilic component in synthesis.

The synthesis of 1-Boc-4-(2-chloroethyl)piperazine typically involves the reaction of N-Boc-piperazine with 1-bromo-2-chloroethane. This straightforward alkylation reaction, often carried out in the presence of a base, yields the desired product. Subsequent purification, commonly through column chromatography, ensures the high purity necessary for demanding synthetic applications. For researchers seeking to buy 1-Boc-4-(2-chloroethyl)piperazine, understanding these synthetic routes can provide insight into product quality.

The reactivity of the compound is primarily dictated by the chloroethyl group. Nucleophiles can attack the carbon atom bearing the chlorine, displacing the chloride ion and forming a new bond. This makes it an excellent reagent for introducing the Boc-protected piperazine moiety into other molecules. Its applications are diverse, ranging from the synthesis of pharmaceutical intermediates to the preparation of specialty chemicals. Exploring the full spectrum of CAS 208167-83-3 chemical uses reveals its importance in creating complex molecular architectures.

Handling and storage recommendations are also important. As with many organic chemicals, it is advisable to store 1-Boc-4-(2-chloroethyl)piperazine in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizing agents. The “For research use only” designation common with such chemicals underscores the need for proper laboratory practices. Ningbo Inno Pharmchem Co., Ltd. ensures that products meet stringent quality standards, providing researchers with the confidence to buy 1-Boc-4-(2-chloroethyl)piperazine for their critical work.