3-Bromo-2-methoxyaniline, identified by its CAS number 116557-46-1, is a compound of significant interest within the fine chemical and pharmaceutical industries. Its unique chemical structure and physical properties make it an indispensable intermediate for various synthesis processes, most notably in the production of Lacosamide, a crucial pharmaceutical agent. This article aims to provide a comprehensive overview of its chemical characteristics and highlight its diverse applications.

The chemical name, 3-Bromo-2-methoxyaniline, accurately describes its molecular composition: an aniline derivative featuring a bromine atom at the meta position and a methoxy group at the ortho position relative to the amino group. This specific halogenated aromatic amine possesses a molecular formula of C7H8BrNO and a molecular weight of 202.048 g/mol. Its physical state is typically a yellowish to brown liquid, with a density of approximately 1.5 g/cm³ and a boiling point of 267.9 °C at standard atmospheric pressure. The flash point, measured at 115.8 °C, indicates its flammability characteristics, which are important for safe handling and storage.

The compound's exact mass is 200.978912, and its topological polar surface area (PSA) is 35.25. The LogP value of 2.06 suggests a moderate lipophilicity, influencing its solubility and partitioning behavior in different solvents. Its vapor pressure at 25°C is negligible at 0.0±0.5 mmHg, and its refractive index is recorded as 1.596. These detailed chemical and physical properties are essential for chemists and process engineers when designing synthetic routes and optimizing reaction conditions. The specification highlights a minimum assay of 98.0%, ensuring the material's suitability for demanding pharmaceutical chemical intermediates applications.

The primary application for 3-Bromo-2-methoxyaniline is its critical role as an intermediate in the synthesis of Lacosamide (CAS: 175481-36-4). Lacosamide is a third-generation antiepileptic drug, and its effective synthesis pathway relies on the precise molecular structure provided by 3-Bromo-2-methoxyaniline. The ability to procure this compound from reliable fine chemical suppliers India is vital for pharmaceutical companies engaged in producing this essential medication.

Furthermore, this compound serves as a versatile building block in general organic synthesis. Its aniline and aryl halide functionalities allow for a wide range of chemical transformations, including coupling reactions, nucleophilic substitutions, and electrophilic aromatic substitutions. This versatility makes it a valuable component for researchers and chemists developing new molecules and fine chemicals. Understanding the nuances of organic synthesis intermediates allows for more efficient and targeted chemical development.

The availability of 3-Bromo-2-methoxyaniline from trusted API intermediates providers is essential for ensuring the quality and consistency of downstream products. For businesses looking to buy 3-Bromo-2-methoxyaniline, focusing on suppliers with robust quality control and documentation is paramount.

In summary, 3-Bromo-2-methoxyaniline is a vital chemical intermediate with well-defined properties and a significant application in the pharmaceutical industry. Its utility in the synthesis of Lacosamide, coupled with its broader potential in organic chemistry, solidifies its importance in the field of fine chemicals.