Piperaquinoline is a chemical compound of significant interest within the pharmaceutical industry, primarily recognized for its role as a key intermediate in the synthesis of antiparasitic and antimalarial drugs. Understanding its chemical properties and how they translate into therapeutic applications is fundamental for researchers and manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. provides an overview of this important compound.

The chemical identity of Piperaquinoline is precisely defined by its CAS number, 4085-31-8, and its molecular formula, C29H32Cl2N6. These identifiers are crucial for ensuring accuracy in chemical synthesis and regulatory documentation. The compound is typically supplied as a white powder, with high purity levels, often exceeding 99%, confirmed through analytical methods like HPLC (High-Performance Liquid Chromatography). This purity is critical, as even minor impurities can affect the efficacy and safety of the final pharmaceutical product. Physical characteristics such as its density (1.292), melting point (257-268°C), and boiling point (721.1°C) are also important parameters for handling, processing, and formulation.

The primary application of Piperaquinoline lies in its function as an antiparasitic intermediate. It plays a crucial role in the mechanism of action of certain antimalarial drugs by inhibiting the heme polymerase of malaria parasites. This inhibition prevents the parasites from converting toxic heme into an inert substance, leading to a buildup of toxic heme and, consequently, the death of the parasite. This makes Piperaquinoline invaluable in combating strains of malaria that have developed resistance to other medications. Its use in combination therapies, particularly with artemisinin derivatives, is a significant advancement in delaying drug resistance and improving treatment outcomes for patients in high-risk malaria areas.

For pharmaceutical companies, sourcing reliable Piperaquinoline powder is essential for consistent drug production. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensure that their Piperaquinoline meets stringent quality controls and industry certifications, making it a trusted choice for API synthesis. By providing high-purity Piperaquinoline, NINGBO INNO PHARMCHEM CO.,LTD. supports the development of life-saving medications that combat widespread parasitic diseases, contributing to global public health initiatives.