For chemists and process engineers involved in pharmaceutical synthesis, a thorough understanding of the properties of key intermediates is fundamental to successful product development. 1-Hydroxyethylethoxypiperazine (CAS: 13349-82-1) is one such compound, vital for the production of important APIs like Quetiapine. Its specific physical and chemical characteristics dictate how it behaves during reactions and influences the overall efficiency and outcome of the synthesis process.

The physical attributes of 1-Hydroxyethylethoxypiperazine, such as its density (approximately 1.0 g/cm³) and boiling point (around 305.7 °C at standard pressure), provide crucial data for process design. These parameters help in determining suitable reaction temperatures, pressures, and separation techniques. Its refractive index and flash point are also important safety and quality indicators. When companies buy 1-Hydroxyethylethoxypiperazine, they rely on this data to ensure it integrates seamlessly into their established protocols.

From a chemical perspective, the presence of both the piperazine ring and the hydroxyl-terminated ether chain makes 1-Hydroxyethylethoxypiperazine a versatile molecule. The nitrogen atoms in the piperazine ring can act as nucleophiles or bases, while the hydroxyl group can participate in esterification, etherification, or other derivatization reactions. This dual functionality is precisely what makes it an effective intermediate for constructing more complex molecular structures like those found in Quetiapine fumarate.

Ensuring the purity of this compound, with minimal levels of related substances like N-Hydroxyethylpiperazine (HEP), is as critical as understanding its inherent properties. Impurities can interfere with reaction pathways, leading to unwanted by-products or incomplete conversion. Therefore, partnering with suppliers like NINGBO INNO PHARMCHEM CO.,LTD., who can provide material with a high assay (≥99.5%) and comprehensive impurity profiles, is essential. This focus on quality enables chemists to fully leverage the chemical properties of 1-Hydroxyethylethoxypiperazine for optimal synthesis results.