For chemists and researchers engaged in complex organic synthesis, a thorough understanding of the chemical properties of intermediates is crucial. (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, bearing the CAS number 1022150-12-4, is a prime example of such a compound. Its molecular formula, C22H22N6O, and molecular weight of 386.45 indicate a sophisticated organic structure that lends itself to specific chemical transformations.

NINGBO INNO PHARMCHEM CO.,LTD. highlights that this compound typically presents as an off-white to pale yellow solid. Its solubility in common organic solvents like DMSO and methanol, albeit described as slightly soluble, is a key characteristic that dictates reaction conditions and purification strategies. Understanding these properties is vital for successful Ibrutinib intermediate synthesis, where precise control over reaction parameters is paramount. The physical form and solubility profile of this pyrazolo-pyrimidine derivative influence how it can be effectively incorporated into larger molecular frameworks.

The optical activity of -9.6828° (C=0.5249g/100ml MeOH) further specifies its chiral nature, which is critical for stereoselective synthesis. This feature is particularly important when dealing with pharmaceutical intermediates where specific enantiomers are required for therapeutic efficacy. As a Bruton's tyrosine kinase inhibitor precursor, maintaining the correct stereochemistry is non-negotiable.

The pKa value of approximately 9.00±0.10 suggests its basic nature, influenced by the amine functionalities within its structure. This property can be leveraged in acid-base reactions, salt formation, or purification via acid extraction. For researchers focusing on fine chemical manufacturing for pharmaceuticals, understanding these acid-base properties is key to optimizing reaction yields and purity. The ability to predict and control the behavior of such compounds is fundamental to efficient API intermediate sourcing.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing researchers with intermediates that meet stringent quality standards. The detailed characterization of (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, including its melting point (133-136°C) and predicted boiling point (626.3±55.0 °C), aids scientists in designing robust and scalable synthetic routes. This comprehensive data supports its effective use as a research chemical in various laboratory settings.