A thorough understanding of a chemical compound's properties is fundamental for its effective use in synthesis and manufacturing. (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, identified by CAS number 129101-37-7, is a fine chemical intermediate whose properties are of significant interest to organic chemists and pharmaceutical researchers. This molecule, often referred to by its IUPAC name (2R)-6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid, possesses a distinct chemical structure that dictates its reactivity and potential applications.

The molecular formula for this compound is C10H9FO3, with a molecular weight of approximately 196.17 g/mol. Key structural features include a dihydro-2H-1-benzopyran core, a fluorine atom attached at the 6-position of the aromatic ring, and a carboxylic acid group at the chiral center in the 2-position of the pyran ring. The 'R' designation signifies its specific enantiomeric configuration, a critical aspect for its use in stereoselective synthesis. Analytical data such as NMR spectroscopy (1H NMR and 13C NMR) provides detailed information about the molecule's structure and connectivity, confirming its identity and purity. For instance, typical NMR shifts confirm the presence and arrangement of protons and carbons within the molecule.

The physical properties of (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid generally describe it as a white solid. Information regarding its boiling point, density, and optical rotation (often reported as a specific rotation value) is important for handling, purification, and application. The presence of the fluorine atom can influence the compound's electronic properties and reactivity, often enhancing lipophilicity or metabolic stability in derived molecules. As a pharmaceutical intermediate, its carboxylic acid group can undergo various reactions, such as esterification or amide formation, enabling its incorporation into larger drug structures.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical intermediates, and understanding these detailed properties is part of our service. When companies look to buy (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, they rely on accurate specifications and reliable analytical data. The availability of this compound, whether as Nebivololo intermediate 3 or another derivative, depends on rigorous quality control, ensuring that its chemical and physical characteristics meet the demanding requirements of pharmaceutical synthesis and research. Sourcing this pharmaceutical intermediate 129101-37-7 from reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that synthetic processes can proceed with confidence and precision.