5-Chlorothiophene-2-carbonyl Chloride (CAS: 42518-98-9) is a chemical compound with distinct physical and chemical properties that dictate its handling and application. As a key intermediate, understanding these characteristics is vital for researchers and manufacturers. Ningbo Inno Pharmchem Co.,Ltd. provides this information to ensure safe and effective utilization of our products.

Physically, 5-Chlorothiophene-2-carbonyl Chloride is typically described as a colorless to pale yellow liquid or powder. It possesses a relatively low melting point, around 4°C, and a boiling point of approximately 225°C. Its density is about 1.5 g/cm³. Chemically, it is an acyl chloride, characterized by a reactive carbonyl chloride group attached to a chlorinated thiophene ring. This functional group makes it highly susceptible to nucleophilic attack. A significant property is its moisture sensitivity; it readily reacts with water, undergoing hydrolysis to form 5-chloro-2-thiophenecarboxylic acid and hydrochloric acid. This hygroscopic nature necessitates storage in tightly sealed containers under dry, inert conditions to maintain its integrity and reactivity.

Due to its reactive nature and the generation of HCl upon hydrolysis, 5-Chlorothiophene-2-carbonyl Chloride is considered a corrosive substance. Therefore, strict safety precautions must be observed during handling. This includes wearing appropriate personal protective equipment (PPE), such as chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in a well-ventilated area, preferably within a fume hood, to avoid inhalation of vapors. Understanding the chemical properties of 5-chlorothiophene-2-carbonyl chloride is crucial for preventing accidents and ensuring product quality.

Proper storage is critical to preserve the quality of 5-Chlorothiophene-2-carbonyl Chloride. It should be stored in a cool, dry, and well-ventilated place, away from moisture and incompatible substances. Keeping containers tightly closed and under an inert atmosphere, such as nitrogen or argon, is highly recommended. For those looking to source this compound, Ningbo Inno Pharmchem Co.,Ltd. emphasizes the importance of adhering to these handling and storage protocols. By prioritizing safety and proper handling, we can collectively advance chemical research and production effectively.