NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing comprehensive information on essential chemical intermediates. Today, we focus on 2,5-Dichloropyrimidine (CAS 22536-67-0), a critical compound in the fine chemical industry, exploring its synthesis routes and widespread applications.

The synthesis of 2,5-Dichloropyrimidine typically involves reactions starting from pyrimidine precursors. One common method involves the treatment of 2-hydroxypyrimidine hydrochloride with aqueous chlorine solution, followed by reaction with phosphoryl chloride in the presence of N,N-dimethylaniline. This process, while yielding the desired product, often requires careful control of reaction conditions and purification steps to achieve high purity.

Alternatively, synthetic pathways can utilize starting materials like (2-chloropyrimidin-5-yl)boronic acid, reacting it with reagents such as N-chlorosuccinimide in the presence of catalysts like cuprous chloride. This approach, often carried out in solvents like acetonitrile and under reflux conditions, demonstrates the diverse chemical strategies employed to obtain 2,5-Dichloropyrimidine.

The applications of 2,5-Dichloropyrimidine are extensive, primarily serving as a key intermediate in the production of pharmaceuticals and agrochemicals. Its role in creating antiviral agents, anticancer drugs, herbicides, and pesticides highlights its significance. The demand for this compound is driven by its utility in developing molecules with targeted biological activities.

For businesses requiring this intermediate, understanding the quality parameters, such as purity (often assayed by GC or HPLC), melting point, and solubility, is vital. Factors such as the price and availability of 2,5-Dichloropyrimidine from reliable suppliers are also critical for efficient procurement and manufacturing.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying high-quality 2,5-Dichloropyrimidine, supporting the diverse needs of the chemical industry. Our expertise ensures that clients receive intermediates that meet stringent specifications, facilitating their research and production endeavors.