For professionals in organic synthesis and chemical research, a thorough understanding of key intermediates is fundamental. 2,4-Dihydroxybenzoic Acid (CAS 89-86-1) is one such compound, offering a rich profile of chemical properties and synthesis pathways that are of significant interest to the scientific community. This article aims to provide researchers with insights into this important chemical.

Chemical Profile and Properties:

2,4-Dihydroxybenzoic Acid is characterized by its molecular formula C7H6O4 and a molecular weight of 154.12 g/mol. It typically presents as an off-white to slightly beige or pink crystalline powder. Its melting point is around 208-217 °C, often with decomposition. The compound exhibits solubility in hot water, ethanol, and ether, and its chemical structure, featuring both phenolic hydroxyl groups and a carboxylic acid group, dictates its reactivity and applications.

Synthesis Pathways and Sourcing:

The synthesis of 2,4-dihydroxybenzoic acid is often achieved through the carboxylation of resorcinol. Researchers interested in obtaining this compound can look for suppliers specializing in pharmaceutical intermediates and fine chemicals. The availability of high-purity 2,4-dihydroxybenzoic acid is crucial for reproducible research outcomes. When planning to buy 2,4-dihydroxybenzoic acid, prioritizing suppliers with detailed specifications and quality control data is advisable.

Applications in Research and Development:

As a pharmaceutical intermediate, 2,4-dihydroxybenzoic acid serves as a vital precursor in the synthesis of various drug molecules. Its functional groups allow for diverse chemical modifications, making it a versatile starting material for medicinal chemistry research. Beyond pharmaceuticals, its antioxidant properties have led to its exploration in cosmetic and food science, further broadening its research applicability.

Handling and Safety:

Standard laboratory safety protocols should be followed when handling 2,4-dihydroxybenzoic acid. It is classified as an irritant (skin, eye, and respiratory tract), and appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should be worn. Proper ventilation is also recommended.

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