NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality chemical intermediates, and 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile (CAS 143782-23-4) stands out for its critical role in pharmaceutical manufacturing. Understanding its synthesis and inherent properties is fundamental for its effective utilization.

The synthesis of 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile typically involves reactions with precursors like 3-trifluoromethyl-4-cyanoaniline. Various reported synthetic routes aim for high product yield and purity, often employing reagents like thiophosgene or phenyl thiochloroformate in specific organic solvents such as dichloromethane or toluene. These methods focus on optimizing reaction conditions to achieve the desired 4-isothiocyanato-2-(trifluoromethyl)benzonitrile synthesis efficiently, making it suitable for industrial production.

Key to its utility are its physical and chemical properties. It is generally presented as a white to off-white solid. The presence of the trifluoromethyl group imparts unique electronic characteristics, influencing its reactivity and the properties of downstream products. The isothiocyanate group (-N=C=S) is highly electrophilic and readily undergoes nucleophilic addition reactions, which is central to its function as a versatile building block in organic synthesis. Familiarity with the 4-isothiocyanato-2-(trifluoromethyl)benzonitrile chemical properties is essential for chemists working with this compound.

As a key Enzalutamide intermediate, the purity of 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile directly impacts the quality of the final drug. Therefore, sourcing from reliable pharmaceutical raw materials suppliers who adhere to stringent quality control measures is paramount. For researchers and manufacturers, obtaining competitive 4-isothiocyanato-2-(trifluoromethyl)benzonitrile price information from trusted sources is a critical part of the procurement process.