The intricate world of organic synthesis relies on a toolkit of versatile intermediates, each offering unique properties to facilitate complex molecular construction. Among these, N-(tert-Butoxycarbonyl)-4-piperidone, commonly known as N-Boc-4-piperidone or Boc-4-piperidone, stands out as a remarkably useful compound. With its established CAS number 79099-07-3, this chemical is a staple in advanced synthetic organic chemistry, particularly in the pharmaceutical sector. Its predictable reactivity and the strategic presence of a tert-butoxycarbonyl (Boc) protecting group make it an ideal starting material for a myriad of transformations, enabling chemists to efficiently build sophisticated molecular architectures.

From a physico-chemical standpoint, N-Boc-4-piperidone presents as a fine, white to light yellow powder. Its purity level, often exceeding 99.0%, is a critical factor for its successful application in sensitive synthetic procedures where trace impurities can lead to undesired byproducts or reduced yields. The compound's molecular formula, C10H17NO3, and a molecular weight of 199.247 g/mol, provide a clear chemical identity. Its melting point, typically falling between 73-77°C, and a boiling point of 289.8±33.0 °C at 760 mmHg, indicate good thermal stability, allowing for a range of reaction conditions. The density of 1.1±0.1 g/cm3 contributes to its practical handling. Crucially, the Boc group attached to the nitrogen atom of the piperidone ring acts as a readily removable protecting group. This feature is fundamental to its utility, allowing for stepwise modifications of the piperidine core without interference from the nitrogen atom.

The application of N-Boc-4-piperidone in organic synthesis is vast and varied. It serves as an excellent starting material for generating various substituted piperidine derivatives, which are common structural motifs in many biologically active compounds. For example, its ketone functionality can be subjected to Grignard reactions, Wittig reactions, or reductive aminations, introducing new substituents at the 4-position of the piperidine ring. The subsequent removal of the Boc group then allows for further functionalization at the nitrogen atom. When considering the purchase of N-Boc-4-piperidone, sourcing from reputable suppliers who ensure consistent quality is paramount. The availability of this compound from N-Boc-4-piperidone manufacturers China often provides a cost-effective solution for research and production scales.

Moreover, N-Boc-4-piperidone is instrumental in the synthesis of complex heterocyclic systems, including bispidines and other polycyclic structures, through reactions like the Mannich reaction. Its role in synthesizing pharmaceutical intermediates for drugs treating conditions ranging from neurological disorders to viral infections highlights its importance in medicinal chemistry. The strategic use of N-Boc-4-piperidone streamlines complex synthetic routes, making it an efficient choice for academic research and industrial production alike. The ability to buy N-tert-butoxycarbonyl-4-piperidone with high assay purity directly impacts the success rate and cost-effectiveness of these intricate synthesis projects.

In summary, N-(tert-Butoxycarbonyl)-4-piperidone is a cornerstone intermediate in modern organic synthesis. Its unique combination of a reactive ketone functionality, the strategically placed Boc protecting group, and its high purity makes it an invaluable tool for chemists. By facilitating the precise construction of complex molecules, it plays a vital role in advancing research in medicinal chemistry, drug development, and the broader field of chemical sciences.