NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of providing high-quality research chemicals that drive scientific discovery. Among our key offerings is AM2394, a compound that has garnered significant attention for its potent activity as a glucokinase activator. Understanding glucokinase function is crucial for unraveling the complexities of glucose metabolism and developing effective treatments for metabolic disorders like type 2 diabetes.

AM2394, identified by its CAS number 1442684-77-6, is a structurally distinct molecule that acts as a potent glucokinase activator (GKA). Its efficacy is well-documented, with an EC50 value of 60 nM, indicating a high affinity and potency in activating glucokinase. This activation is critical because glucokinase plays a pivotal role in glucose sensing and insulin secretion, processes that are often impaired in individuals with diabetes. By enhancing glucokinase's affinity for glucose, AM2394 helps to normalize glucose levels, a significant benefit in the context of diabetes research.

One of the most exciting aspects of AM2394 is its oral bioavailability. This characteristic is paramount for therapeutic development, as it allows for convenient administration and effective systemic action. In preclinical studies, AM2394 has demonstrated a robust reduction in plasma glucose levels during oral glucose tolerance tests (OGTT) in animal models, specifically in ob/ob mice, which are commonly used to study type 2 diabetes. The compound has shown good-to-moderate cross-species plasma clearance and volume of distribution, suggesting its potential for broader application in various animal research models. The ability to purchase AM2394 for these studies empowers researchers to delve deeper into the therapeutic potential of glucokinase activation.

The impact of AM2394 extends across various fields of research. For those in the pharmaceutical industry, it represents a valuable compound for drug discovery and development, particularly for novel antidiabetic agents. Its role as a metabolic research compound allows scientists to investigate glucose homeostasis, insulin sensitivity, and the underlying mechanisms of metabolic diseases. When sourcing pharmaceutical intermediates, quality and reliability are paramount. NINGBO INNO PHARMCHEM CO.,LTD. ensures that AM2394 meets stringent quality standards, making it a trusted choice for demanding research applications. The competitive price of AM2394 further enhances its accessibility for academic and industrial research laboratories.

In summary, AM2394 stands out as a critical tool for advancing our understanding of glucose metabolism and diabetes. Its potent glucokinase activation, coupled with its oral bioavailability, positions it as a key player in metabolic research and a promising candidate for future therapeutic interventions. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this essential compound, supporting the groundbreaking work of scientists worldwide. Whether you are looking to buy AM2394 for fundamental research or for your drug development pipeline, our commitment to quality and customer satisfaction remains unwavering.