For any chemical compound to be effectively utilized in research and development, understanding its fundamental properties, such as purity and solubility, is paramount. Niclosamide, a compound of significant therapeutic interest, is no exception. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of high purity and well-defined solubility for Niclosamide to ensure reliable and reproducible experimental results, particularly in areas like Niclosamide anticancer activity and STAT3 inhibition.

Niclosamide, identified by CAS number 50-65-7, is typically supplied as a pale yellow crystalline powder. Its purity levels are critical, with most research-grade Niclosamide exceeding 98% or even 99%. High purity ensures that observed biological effects are directly attributable to Niclosamide itself, minimizing confounding factors from impurities. For instance, when investigating Niclosamide STAT3 inhibition, even minor impurities could potentially interfere with the assay results or lead to misinterpretations regarding the compound's specific mechanism of action.

Solubility is another crucial parameter. Niclosamide is known to be practically insoluble in water but shows good solubility in organic solvents like DMSO and ethanol. Typically, it is soluble in DMSO at concentrations around 14 mg/ml and in ethanol at approximately 6 mg/ml. These solubility characteristics dictate how Niclosamide is prepared for in vitro and in vivo studies. For example, preparing stock solutions for cell-based assays requires careful selection of the solvent and precise concentration calculations to achieve the desired working concentrations. Understanding the Niclosamide solubility profile is essential for formulating effective experimental protocols.

Researchers investigating Niclosamide's multifaceted roles, from its established anthelmintic properties to its emerging potential as an autophagy inducer and anticancer agent, must pay close attention to these physicochemical details. The effectiveness of Niclosamide in inhibiting parasitic organisms, inducing autophagy, or targeting cancer pathways is directly influenced by the quality and preparation of the compound used.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing Niclosamide that meets stringent quality standards. Our focus on Niclosamide purity and solubility ensures that scientists can confidently incorporate our products into their critical research, accelerating the discovery of new therapeutic applications for this versatile compound.