The synthesis of peptides, complex molecules fundamental to life, relies on precise and controlled chemical reactions. At the heart of modern peptide manufacturing lies the Fmoc (9-fluorenylmethoxycarbonyl) protection strategy, and integral to this is the use of protected amino acid derivatives. NINGBO INNO PHARMCHEM CO.,LTD. highlights the significance of Fmoc-Asn-OH, a key building block that empowers researchers in their quest to create novel peptides for therapeutic and research purposes.

Fmoc-Asn-OH, with the CAS number 71989-16-7, is N-alpha-Fmoc-L-asparagine. This compound is characterized by its white to off-white crystalline powder appearance. Its molecular weight is approximately 354.36 g/mol, and its chemical formula is C19H18N2O5. These specifications are crucial for ensuring accurate stoichiometry and successful reaction yields in peptide synthesis. The stability of Fmoc-Asn-OH under appropriate storage conditions (typically refrigerated) is also a vital consideration for laboratories.

In the context of solid-phase peptide synthesis (SPPS), Fmoc-Asn-OH plays a direct role in introducing the asparagine residue. Asparagine is an important amino acid with a polar amide side chain, capable of participating in crucial hydrogen bonding interactions that influence peptide structure and biological activity. The accurate incorporation of asparagine is therefore critical for mimicking natural peptide sequences or for designing peptides with specific functionalities. The ability to reliably source high-purity Fmoc-Asn-OH from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is essential for achieving reproducible results.

The applications of Fmoc-Asn-OH in SPPS are extensive. It is used in the synthesis of peptides for a wide array of fields, including pharmaceuticals, cosmetics, and biochemical research. For instance, in the pharmaceutical industry, Fmoc-Asn-OH is used to create peptide-based drugs targeting various diseases. Its inclusion in complex sequences contributes to the overall pharmacological profile of the synthesized peptide, influencing its efficacy, stability, and bioavailability.

Researchers actively leverage the advantages of Fmoc-Asn-OH in peptide synthesis to achieve high yields and purities. The Fmoc group’s lability under basic conditions, coupled with the acid lability of most side-chain protecting groups, allows for a strategic and orthogonal deprotection process. This strategy minimizes side reactions and simplifies purification, making it the method of choice for many complex peptide targets.

To summarize, Fmoc-Asn-OH is a fundamental component in the toolkit of any peptide chemist. Its precise chemical nature, coupled with its critical role in SPPS, makes it an indispensable reagent for scientific advancement. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are instrumental in providing the high-quality materials that drive innovation in peptide research and development.