The utility of 1-Phenoxy-2-propanol (CAS 770-35-4) across diverse industries is deeply rooted in its specific chemical properties and the efficient synthesis methods employed for its production. Understanding these aspects provides valuable insight into why this glycol ether is so highly regarded for its performance as a preservative, solvent, and stabilizer.

Industrially, 1-Phenoxy-2-propanol is primarily synthesized through the reaction of propylene oxide with phenol. This process typically occurs in the presence of a catalyst, such as aluminum oxide-magnesium oxide/iron oxide (Al2O3-MgO/Fe3O4). The reaction involves the opening of the epoxide ring of propylene oxide and subsequent addition to the phenolic hydroxyl group. The conditions of this reaction, including temperature, pressure, and catalyst type, are carefully controlled to optimize yield and purity.

Another common synthetic route involves the reaction of phenol with 1-chloropropan-2-ol in the presence of a base like sodium hydroxide. This nucleophilic substitution reaction displaces the chlorine atom, forming the ether linkage characteristic of 1-Phenoxy-2-propanol. The choice of synthetic pathway often depends on factors such as the availability of raw materials, desired purity levels, and economic considerations.

The resulting 1-Phenoxy-2-propanol is a colorless to pale yellow liquid with a mild, pleasant odor. Its chemical formula is C9H12O2, and it has a molecular weight of approximately 152.19 g/mol. A key property that contributes to its broad applicability is its excellent solubility. It readily dissolves in water, alcohols, and many other organic solvents, making it an effective co-solvent in various formulations.

Key physical properties include a boiling point around 243°C and a flash point exceeding 230°F (104.4°C), indicating its relative stability and combustibility rather than high flammability. Its density is approximately 1.064 g/mL at 20°C, and its refractive index is around 1.523. These characteristics ensure ease of handling and incorporation into different product matrices.

For manufacturers seeking consistent quality and reliable supply of this critical chemical, partnering with established suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is essential. Ensuring the purity and specifications of 1-Phenoxy-2-propanol are met is vital for achieving the desired performance in end products. The careful synthesis and understanding of its chemical properties are fundamental to its continued success in the market.