At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to supplying chemicals that are fundamental to scientific exploration and innovation. One such compound is 2-(Bis(2-hydroxyethyl)amino)acetic Acid, widely recognized as Bicine. This molecule is a cornerstone in various scientific disciplines, primarily for its role as a robust biochemical buffer and its intriguing implications in biomedical research.

Bicine functions as a zwitterionic amino acid buffer, characterized by its pKa of 8.26 at 25°C, making it highly effective for maintaining stable pH levels in the range of 7.6 to 9.0. This stability is crucial for numerous biochemical processes, including enzyme assays like the determination of guanine deaminase. Researchers frequently opt for Bicine in low-temperature biochemical work due to its reliable buffering capacity under such conditions. The precision afforded by using a quality 2-(Bis(2-hydroxyethyl)amino)acetic acid buffer is paramount for achieving accurate and reproducible experimental outcomes.

Beyond its buffering capabilities, Bicine has garnered attention for its influence on protein aggregation, particularly concerning amyloid-beta (Aβ) peptides, which are central to neurodegenerative diseases like Alzheimer's. Scientific literature indicates that Bicine can promote the rapid formation of β-sheet-rich amyloid-beta fibrils. This effect makes Bicine a valuable tool for researchers investigating the mechanisms of protein misfolding and developing potential therapeutic targets. Understanding how to promote amyloid-beta fibrils formation accurately relies on consistent reagents like Bicine.

The application of Bicine also extends to protein science, where it is employed in techniques such as protein crystallization and as a component in buffer systems for gel electrophoresis. Its presence in these methods aids in achieving better separation and structural determination of proteins, critical for understanding their biological roles. For scientists looking to buy high-grade Bicine for these intricate studies, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable source.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to upholding the highest standards of purity and quality for all our chemical products, including Bicine. We understand the critical nature of laboratory reagents in achieving scientific breakthroughs. Our rigorous quality control ensures that researchers and manufacturers can depend on our Bicine for consistent performance and accurate results, whether it's for precise biochemical assays or for advanced biomedical research.

In essence, Bicine is a scientifically significant compound with broad utility. Its efficacy as a buffer and its role in elucidating complex biological processes, such as protein aggregation, highlight its importance in modern science. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this essential chemical, empowering advancements in biochemistry and biomedical research.