NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality chemical reagents that are fundamental to scientific discovery. Among our extensive catalog, 2-(Bis(2-hydroxyethyl)amino)acetic Acid, or Bicine, stands out for its remarkable versatility. This compound is highly valued in the scientific community for its efficacy as a biochemical buffer and its applications in protein-related studies, underscoring its importance in research and development.

As a zwitterionic amino acid buffer, Bicine offers excellent buffering capacity in the physiological pH range, specifically from 7.6 to 9.0, with a pKa of 8.26 at 25°C. This property makes it an indispensable tool for maintaining stable pH conditions in various biological experiments. Laboratories often use Bicine for low-temperature biochemical work, where maintaining precise pH is critical for the stability and activity of biomolecules. The consistent performance of Bicine ensures the reliability of results in sensitive assays, such as those for guanine deaminase determination. When researchers need to buy high-quality Bicine for these applications, NINGBO INNO PHARMCHEM CO.,LTD. is a trusted source.

The utility of Bicine extends significantly into the realm of protein science. It has been successfully employed in protein crystallization, a vital step in determining the three-dimensional structures of proteins, which is crucial for understanding their function and for drug design. Furthermore, Bicine has been incorporated into buffer systems for techniques like SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis), enhancing the resolution and separation of proteins and peptides. This application is particularly important for complex samples, where achieving clear separation is paramount for accurate analysis. The effectiveness of bicine in protein crystallization highlights its broad impact.

In addition to its roles in biochemistry and protein science, Bicine is also recognized for its influence on the aggregation of amyloid-beta peptides. Research indicates that Bicine can accelerate the formation of beta-sheet-rich amyloid-beta fibrils, a key process in the development of Alzheimer's disease. This finding positions Bicine not only as a laboratory reagent but also as a compound of interest in the study of protein misfolding disorders. Exploring the nuances of promoting amyloid-beta fibrils formation often requires precisely characterized reagents like Bicine.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying Bicine with the highest purity, ensuring that it meets the demanding standards of biochemical and protein research. Our commitment to quality control guarantees that our clients receive a reliable product for all their experimental needs. The consistent performance of our Bicine supports advancements in understanding biological processes and developing new biotechnologies. Choosing the right supplier for your 2-(Bis(2-hydroxyethyl)amino)acetic acid buffer needs is critical for experimental success.

In summary, Bicine is a remarkable chemical compound whose applications span from fundamental biochemical buffering to sophisticated protein analysis and cutting-edge biomedical research. Its stability, versatility, and unique interactions with biological molecules solidify its position as a key reagent. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to the scientific community by providing superior quality Bicine, empowering researchers to push the boundaries of knowledge.