Propofol Injection is generally considered safe and effective in veterinary practice when used appropriately. However, like any potent medication, it carries potential risks, one of the most serious being Propofol Infusion Syndrome (PRIS). While rare, PRIS is a critical condition associated with prolonged, high-dose infusions of Propofol and requires a thorough understanding by veterinary professionals.

PRIS is characterized by a constellation of metabolic disturbances and organ system dysfunction. Key features include metabolic acidosis, rhabdomyolysis (muscle breakdown), hyperlipidemia (high blood fat levels), cardiac dysfunction, and kidney failure. The exact mechanism is not fully understood but is thought to involve impaired mitochondrial fatty acid metabolism. In veterinary medicine, PRIS is more commonly observed in patients receiving continuous high-dose Propofol infusions for extended periods, often exceeding 48 hours, or at doses higher than typically recommended for routine anesthesia. Critically ill patients, especially those also receiving catecholamines or steroids, may be at increased risk.

Recognizing the early signs of PRIS is crucial for timely intervention. Symptoms can include refractory bradycardia (slow heart rate) progressing to asystole, increased anion gap metabolic acidosis, and elevations in creatine kinase or triglycerides. The immediate step upon suspicion of PRIS is to discontinue the Propofol infusion and provide supportive care. Given the potential for severe outcomes, vigilance in monitoring patients on prolonged Propofol infusions is essential. Sourcing high-quality Propofol Injection from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is fundamental, as product integrity is key. While the risk of PRIS is low with standard veterinary protocols, awareness and preparedness are vital for safeguarding animal patients undergoing intensive or prolonged sedation.