Maintaining the integrity of our genetic material is fundamental to cellular health and preventing disease. Nicotinamide Adenine Dinucleotide (NAD+) plays a pivotal role in this process, particularly in DNA repair mechanisms. When DNA damage occurs, such as through exposure to UV radiation or other environmental stressors, cells rely on NAD+ to activate repair enzymes like Poly(ADP-ribose) polymerases (PARPs).

PARPs utilize NAD+ as a substrate to synthesize poly(ADP-ribose) (PAR) chains. These PAR chains act as signaling molecules, recruiting other DNA repair proteins to the site of damage. This coordinated effort ensures that breaks and errors in the DNA are efficiently fixed, thereby maintaining genomic stability. Without sufficient NAD+, the effectiveness of these DNA repair pathways is compromised, potentially leading to an accumulation of mutations and increased cellular dysfunction.

The link between NAD+ and DNA repair highlights its importance in cellular defense. As we age, our natural NAD+ levels decline, which can impair the body's ability to repair DNA damage effectively. This is where supplementation, often with NAD+ precursors like NMN or NR, becomes relevant. NINGBO INNO PHARMCHEM CO.,LTD. supplies these essential compounds, supporting research into how NAD+ can bolster cellular defense systems.

Furthermore, NAD+ is involved in regulating the activity of sirtuins, a family of proteins known for their roles in DNA repair, gene expression, and cellular longevity. Sirtuins require NAD+ to function, acting as deacetylases that influence the activity of various cellular proteins. By supporting sirtuin function, NAD+ indirectly contributes to maintaining cellular health and combating the effects of aging.

Understanding the functions of NAD+ in the body, especially its role in DNA repair, underscores its significance for overall health. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality NAD+ and its precursors to researchers and industries exploring these critical cellular processes. By ensuring adequate NAD+ levels, we empower cells to better manage DNA damage and maintain their integrity.