Bronopol (CAS 52-51-7): A Deep Dive into its Properties and Manufacturing
Bronopol, scientifically known as 2-bromo-2-nitropropane-1,3-diol and carrying the CAS number 52-51-7, is an organic compound prized for its potent antimicrobial capabilities. Understanding its inherent properties and the manufacturing processes behind it is crucial for appreciating its widespread use. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of this high-quality chemical.
Physically, Bronopol typically appears as a white to off-white crystalline powder. Its solubility in water and polar solvents like propylene glycol and isopropanol is a key advantage, allowing for easy incorporation into aqueous formulations. While pure Bronopol is white, commercial samples can sometimes exhibit a pale yellow hue due to minor iron chelation during manufacturing, a characteristic that does not impede its efficacy. Its melting point is generally reported in the range of 130-133 °C, though it can undergo crystalline rearrangement at lower temperatures.
Chemically, Bronopol is an aliphatic halogenonitro compound. Its stability is notable under acidic conditions, but it is susceptible to decomposition in alkaline environments and at elevated temperatures. This decomposition can lead to the liberation of formaldehyde, nitrite ions, and other compounds. The molecule's structure, featuring a bromine atom and a nitro group, is central to its antimicrobial action, enabling it to disrupt cellular processes by interacting with vital enzyme thiol groups.
The synthesis and production of Bronopol typically involves the bromination of nitromethane derivatives. Historically, it was developed by The Boots Company PLC in the early 1960s. Today, its global manufacturing is robust, with a significant portion of production originating from China, driven by cost-effectiveness and scale. NINGBO INNO PHARMCHEM CO.,LTD. plays a role in this landscape by ensuring the consistent availability of high-purity Bronopol, meeting international quality standards.
The manufacturing landscape for Bronopol is characterized by large-scale production facilities focused on efficiency and quality control. Manufacturers pay close attention to controlling reaction parameters to ensure high assay percentages (typically ≥99.0%) and minimize impurities. Packaging is usually in drums or bags, and storage recommendations emphasize cool, dry, and well-ventilated conditions, protected from direct sunlight and moisture, and importantly, kept separate from incompatible materials like strong oxidizers or bases.
The enduring relevance of Bronopol across industries speaks to its well-understood properties and reliable performance. By offering high-quality Bronopol, NINGBO INNO PHARMCHEM CO.,LTD. supports the diverse needs of its clients, from cosmetic formulators to industrial water treatment specialists. Understanding the fundamental properties and manufacturing origins of Bronopol allows for its most effective and responsible application.
Perspectives & Insights
Agile Reader One
“Its melting point is generally reported in the range of 130-133 °C, though it can undergo crystalline rearrangement at lower temperatures.”
Logic Vision Labs
“Its stability is notable under acidic conditions, but it is susceptible to decomposition in alkaline environments and at elevated temperatures.”
Molecule Origin 88
“This decomposition can lead to the liberation of formaldehyde, nitrite ions, and other compounds.”