Rh-Catalyzed Asymmetric Synthesis for Pharmaceutical Intermediates
Discover advanced rhodium catalysts for precise enantioselective hydrogenation and reduction in pharmaceutical development.
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![(1Z,5Z)-cyclooctadiene,(S)-(2-methoxyphenyl)-[2-[(2-methoxyphenyl)-phenylphosphanyl]ethyl]-phenylpho](https://www.nbinno.com/2025/webimg/gemini_688b3a9553877_1753954965.png)
(1Z,5Z)-cyclooctadiene,(S)-(2-methoxyphenyl)-[2-[(2-methoxyphenyl)-phenylphosphanyl]ethyl]-phenylphosphane,rhodium,tetrafluoroborate
This advanced organometallic compound serves as a potent and highly reactive enantioselective catalyst, crucial for achieving high yields and purity in complex chemical syntheses, particularly within the pharmaceutical and fine chemical sectors. Its specific stereochemistry ensures targeted reaction pathways.
- Achieve superior N-protected amino acid synthesis through highly selective asymmetric hydrogenation of dehydroalanines.
- Facilitate the effective asymmetric reduction of pentapeptides containing unsaturated linkages, a key step in producing vital peptide hormones like enkephalin.
- Benefit from the catalyst's efficiency in the asymmetric reduction of enol acetates to esters, broadening its utility in organic synthesis.
- Expertly prepare chiral 2-substituted succinic acid derivatives, essential building blocks for numerous active pharmaceutical ingredients (APIs).
Key Advantages of Our Catalyst
Unparalleled Enantioselectivity
Leverage the catalyst's precisely engineered chiral environment to achieve exceptional enantiomeric excess in your target molecules, crucial for pharmaceutical applications.
High Reactivity & Efficiency
Experience significantly reduced reaction times and improved yields due to the catalyst's inherent high reactivity, optimizing your production processes.
Versatile Synthetic Applications
Utilize this single catalyst across a range of challenging transformations, including asymmetric hydrogenation and reduction, streamlining your research and development efforts.
Key Applications
Pharmaceutical Synthesis
Crucial for the synthesis of chiral intermediates and active pharmaceutical ingredients (APIs), enabling precise control over stereochemistry.
Peptide Chemistry
Essential for the modification of peptides, such as the conversion of unsaturated amino acid residues into specific peptide hormones.
Fine Chemical Manufacturing
Supports the production of high-value fine chemicals that require specific stereoisomers for their functionality.
Chiral Building Blocks
Facilitates the creation of chiral building blocks, which are fundamental components in the development of new drugs and materials.
Related Technical Articles & Resources
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Global Experience
With 20 years of R&D, manufacturing, and sales experience, we proudly serve clients across 60 countries and regions worldwide.
Advanced Facilities
Our in-house R&D laboratory, pilot platform, and large-scale production workshop are equipped to meet the audit requirements of global customers.
Seamless Scalability
We facilitate a perfect transition from small-scale lab requirements (grams) to full commercialization (hundreds of tons).