5-Benzylthio-1H-tetrazole: A Versatile Heterocycle for Peptide Synthesis and Medicinal Chemistry
An essential organic chemical material for advanced synthesis and drug discovery.
Get a Quote & SampleProduct Core Value
5-Benzylthio-1H-tetrazole
This sulfur-containing heterocycle is a highly versatile organic chemical material. It serves as an efficient coupling reagent specifically for phosphoramidite chemistry in oligonucleotide synthesis, making it crucial for DNA/RNA automated synthesizers. The presence of the benzylthio group is advantageous as it enhances solubility in various organic solvents while successfully maintaining its intended reactivity.
- Discover the crucial role of 5-Benzylthio-1H-tetrazole in peptide synthesis, enabling efficient coupling reactions.
- Explore how this organic chemical material, 21871-47-6, facilitates advanced nucleotide chain elongation.
- Learn about the advantages of using a tetrazole derivative coupling reagent for improved synthesis yields.
- Investigate the broad utility of this compound in medicinal chemistry applications and drug discovery programs.
Key Product Advantages
Enhanced Solubility
The benzylthio group in 5-Benzylthio-1H-tetrazole significantly enhances its solubility in common organic solvents, simplifying handling and reaction processes in various chemical synthesis workflows.
High Reactivity
As a potent coupling reagent, this tetrazole derivative offers high reactivity, leading to efficient bond formation in oligonucleotide synthesis and other complex molecular constructions.
Broad Applicability
Beyond its primary use in nucleotide synthesis, 5-Benzylthio-1H-tetrazole is valuable in medicinal chemistry, serving as a precursor for bioactive tetrazole derivatives and in click chemistry applications.
Key Applications
Oligonucleotide Synthesis
Leverage the efficiency of 5-Benzylthio-1H-tetrazole as a coupling reagent in DNA/RNA automated synthesizers, ensuring high yields in nucleotide chain elongation.
Medicinal Chemistry
Utilize this compound as a key precursor for developing novel bioactive tetrazole derivatives with potential therapeutic applications in drug discovery.
Click Chemistry
Incorporate 5-Benzylthio-1H-tetrazole into click chemistry protocols for efficient and reliable bioconjugation and material science applications.
Catalysis
Employ this heterocycle as a ligand in transition metal catalysis, opening pathways for novel catalytic transformations in organic synthesis.