DEPBT: A Superior Peptide Coupling Reagent for Amide Bond Formation with Exceptional Racemization Resistance
Discover the power of DEPBT for efficient and stereoselective amide bond synthesis in your organic chemistry projects.
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3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one
This advanced coupling reagent, often referred to as DEPBT, is engineered for superior performance in amide bond formation. Its key advantage lies in its exceptional resistance to racemization, a critical factor when synthesizing enantiomerically pure compounds, making it a preferred choice over traditional phosphonium and uronium reagents.
- Leverage DEPBT for exceptional resistance to racemization in complex peptide synthesis, ensuring the stereochemical integrity of your target molecules.
- Achieve highly efficient amide bond formation through a unique mechanism that minimizes side reactions and maximizes product yield.
- Benefit from its versatility in organic synthesis, enabling the coupling of a wide range of carboxylic acids and amines under mild conditions.
- Utilize this stable compound, which offers a long shelf life, as a reliable component in your peptide synthesis workflow.
Key Advantages Offered
Minimized Racemization
DEPBT significantly reduces epimerization during coupling reactions, a crucial factor for synthesizing pure enantiopure amino acids and peptides, crucial for drug development.
Enhanced Coupling Efficiency
The reagent facilitates efficient amide bond formation by activating carboxylic acids, leading to higher yields and cleaner reaction profiles compared to many other coupling agents.
Broad Applicability
DEPBT demonstrates versatility across a wide spectrum of carboxylic acids and amines, making it an indispensable tool for various organic synthesis endeavors.
Key Applications
Peptide Synthesis
As a leading peptide coupling reagent, DEPBT is vital for constructing peptide chains, especially when dealing with sensitive amino acid sequences prone to racemization.
Organic Synthesis
DEPBT serves as a powerful tool in general organic synthesis for creating amide bonds in complex molecules and intermediates, contributing to diverse chemical research.
Pharmaceutical Development
Its ability to maintain stereochemical purity makes DEPBT invaluable in the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive compounds.
Amide Bond Formation
This reagent offers a reliable method for the direct synthesis of amide bonds, a fundamental transformation in the creation of a vast array of organic molecules.